Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease

Last updated: October 8, 2014
Sponsor: University of Roma La Sapienza
Overall Status: Completed

Phase

3

Condition

Heart Disease

Hypercholesterolemia

Carotid Artery Disease

Treatment

N/A

Clinical Study ID

NCT02260453
University "La Sapienza" Rome
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to evaluate the potential benefit of systematic preoperative coronary angiography followed by selective coronary artery revascularization on the incidence of myocardial infarction (MI) in patients without a history of coronary artery disease (CAD) and undergoing carotid endarterectomy (CEA).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • indication for carotid endarterectomy

  • no clinical sign or history of ischemic heart disease

  • no electrical signs of cardiac ischemia

  • left ventricular ejection fraction >50% at transthoracic echocardiogram.

Exclusion

Exclusion Criteria:

  • disabling stroke (mRS ≥3)

  • non atherosclerotic carotid disease

  • severe intracranial carotid artery stenosis

  • contra-indications to heparin, aspirin or clopidogrel.

Study Design

Total Participants: 426
Study Start date:
January 01, 2005
Estimated Completion Date:
June 30, 2012

Study Description

Patients candidates for CEA, with no history of CAD, a normal electrocardiogram (ECG), and a normal cardiac ultrasound were randomized in two groups. In group A (n = 216) all patients underwent coronary angiography before CEA +- coronary artery revascularization. In group B (n = 210) CEA was performed without coronary angiography.