The Influence of PRN Dry Eye Omega-3 Nutritional Regimen on Tear Osmolarity In Cases Of Dry Eye Disease

Inclusion Criteria:

• Age ≥18 and ≤ 90 at the time of informed consent

• Subjects experiencing dry eye based on a global clinical assessment by the attendingclinician, subject complaint of dry eye symptoms

• Presence or History of Tear Osmolarity (Appendix 2) equal to or greater than 312mOsm/L in at least one eye

• Presence or History of Meibomian Gland Dysfunction (Grade 1 or 2) in at least one eye

Exclusion Criteria:

• Allergy to fish oil or safflower oil

• Clinically significant eyelid deformity or eyelid movement disorder that is caused byconditions such as notch deformity, incomplete lid closure, entropion, ectropion,hordeola or chalazia

• Previous ocular disease leaving sequelae or requiring current topical eye therapyother than for DED, including, but not limited to: active corneal or conjunctivalinfection of the eye and ocular surface scarring Active ocular or nasal allergy

• LASIK or PRK surgery that was performed within one year of the Screening Visit or atany time during the study

• Ophthalmologic drop use within 2 hours of any study visits. Any OTC habitualartificial tear should be continued at the same frequency and no change in drop brand

• Contact lens wear within 12 hours of any study visits

• Pregnancy or lactation during the study

• Abnormal nasolacrimal drainage (by history)

• Punctal cauterization or punctal plug placement within 60 days of screening

• Prohibited Medications - Cyclosporine (Restasis®); any topical prescriptionmedications (i.e., steroids, NSAIDs, etc); glaucoma medications; oral tetracyclines ortopical macrolides; oral nutraceuticals (flax, black currant seed oils, etc…) within 3weeks (21 days) of Screening and at any time during the study