Novel Approach to Radiotherapy in Locally Advanced Lung Cancer Concomitant Navelbine®

Last updated: April 22, 2022
Sponsor: Olfred Hansen
Overall Status: Active - Recruiting

Phase

N/A

Condition

Non-small Cell Lung Cancer

Treatment

N/A

Clinical Study ID

NCT02354274
NARLAL 2
  • Ages > 18
  • All Genders

Study Summary

To investigate the effect of escalation of radiation dose to tumor and lymph nodes based on an inhomogeneous dose distribution controlled by FDG-PET positive areas compared to a standard homogeneous dose spread

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with histologically or cytologically proven locally advanced NSCLC stage IIBto IIIB
  • Performance status 0-1
  • Able to comply with treatment and follow study and follow-up procedures
  • Women must have negative pregnancy test
  • Signed, informed consent
  • Plan for radiotherapy with conventional 66 Gy/ 33 F, which meets all dosing limits twonormal tissue must be available

Exclusion

Exclusion Criteria:

  • Any unstable systemic disorder (including infection , unstable angina, congestiveheart failure , severe liver , kidney or metabolic disease)
  • Need for nasal oxygen
  • Former thoracic radiotherapy, unless there is no significant overlap with previousfields
  • Any other active malignant disease
  • Unable to take oral medications or needing intravenous nutrition
  • Ulcer
  • Nursing women

Study Design

Total Participants: 330
Study Start date:
January 01, 2015
Estimated Completion Date:
October 31, 2029

Study Description

To investigate the effect of escalation of radiation dose to tumor and lymph nodes based on an inhomogeneous dose distribution controlled by FDG-PET-positive areas compared to a standard homogeneous dose spread.

Connect with a study center

  • Aalborg University Hospital

    Aalborg, 9100
    Denmark

    Site Not Available

  • Aarhus University Hospital

    Aarhus, 8000
    Denmark

    Active - Recruiting

  • Rigshospitalet

    Copenhagen, 2100
    Denmark

    Site Not Available

  • Herlev University Hospital

    Herlev, 2730
    Denmark

    Active - Recruiting

  • Department of Oncology, Naestved Hospital

    Naestved,
    Denmark

    Site Not Available

  • Department of Oncology, Odense University Hospital

    Odense, 5000
    Denmark

    Active - Recruiting

  • Department of Oncology, Vejle Hospital

    Vejle, 7100
    Denmark

    Active - Recruiting

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