The EUROSCA Natural History Study

Last updated: June 28, 2017
Sponsor: Ataxia Study Group
Overall Status: Active - Recruiting

Phase

N/A

Condition

Spinocerebellar Disorders

Treatment

N/A

Clinical Study ID

NCT02440763
010/05
  • Ages > 18
  • All Genders

Study Summary

The key goals of EUROSCA-NHS is to determine and compare the rate of disease progression in SCA1, SCA2, SCA3 and SCA6 including determination of the order and occurrence of non-ataxia symptoms, assessment of activities of daily living (ADL) and quality of life (QoL), and identification of predictors of disease progression and survival.

Eligibility Criteria

Inclusion

Inclusion criteria:

  • Progressive, otherwise unexplained ataxia

  • Positive genetic testing for SCA1, SCA2, SCA3, and SCA6

  • Written informed consent by the patient or his legal agent

Exclusion

Exclusion criteria:

Study Design

Total Participants: 400
Study Start date:
July 01, 2005
Estimated Completion Date:
July 31, 2050

Study Description

The key goal of EUROSCA-NHS is to determine and compare the rate of disease progression in SCA1, SCA2, SCA3 and SCA6. To this end, a newly developed and validated ataxia scale (Scale for the Assessment and Rating of Ataxia, SARA) will be used. EUROSCA-NHS has a number of secondary aims including determination of the order and occurrence of non-ataxia symptoms, assessment of activities of daily living (ADL) and quality of life (QoL), and identification of predictors of disease progression and survival. Substudies will deal with the development of brain atrophy, as assessed by magnetic resonance imaging (MRI), progression of peripheral neuropathy, as assessed by nerve conduction studies, and specific clinical aspects of SCA.

Connect with a study center

  • Department of Neurology, Medical University, Innsbruck

    Innsbruck,
    Austria

    Site Not Available

  • Université Libre de Bruxelles (ULB), Neurology Service - ULB Hôpital Erasme, ULB Laboratory of Experimental Neurology

    Brussels,
    Belgium

    Site Not Available

  • Hôpital de la Pitié-Salpêtrière, Département de Génétique

    Paris,
    France

    Site Not Available

  • Department of Neurology, St. Josef Hospital, University Hospital of Bochum

    Bochum,
    Germany

    Site Not Available

  • Department of Neurology, University of Bonn

    Bonn, 53105
    Germany

    Active - Recruiting

  • Department of Neurology, University Clinic Essen, University of Duisburg-Essen

    Essen,
    Germany

    Site Not Available

  • Department of Neurology, University of Frankfurt

    Frankfurt,
    Germany

    Site Not Available

  • Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tübingen

    Tübingen,
    Germany

    Site Not Available

  • Department of Medical Genetics, University of Pecs

    Pecs,
    Hungary

    Site Not Available

  • Department of Neurology, Zala County Hospital

    Zalaegerszeg,
    Hungary

    Site Not Available

  • Fondazione-IRCCS Istituto Neurologico Carlo Besta

    Milan,
    Italy

    Site Not Available

  • Department of Neuroscience, Federico II University Naples

    Naples,
    Italy

    Site Not Available

  • Radboud University Medical Center, Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour

    Nijmegen,
    Netherlands

    Site Not Available

  • Institute of Psychiatry and Neurology

    Warsaw,
    Poland

    Site Not Available

  • University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria

    Santander,
    Spain

    Site Not Available

  • Institute of Neurology

    London,
    United Kingdom

    Site Not Available

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