The Use of 5mg Finasteride Versus 200mg Spironolactone and Topical 5% Minoxidil in Treating Postmenopausal Female Androgenetic Alopecia

Last updated: August 31, 2016
Sponsor: University of Florida
Overall Status: Trial Not Available

Phase

4

Condition

Alopecia

Hair Loss

Treatment

N/A

Clinical Study ID

NCT02483195
IRB201500433
  • Ages > 60
  • Female
  • Accepts Healthy Volunteers

Study Summary

The investigators propose to conduct a head-to-head, randomized clinical trial to compare the effectiveness of Minoxidil with Spironolactone and Finasteride in treating postmenopausal females with Androgenetic Alopecia (AGA).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • female

  • postmenopausal (>60 years old or with total hysterectomy)

  • diagnosed with androgenetic alopecia

  • no chemical processing or changes in hair products throughout the study

Exclusion

Exclusion Criteria:

  • men

  • premenopausal women (<60 or without hysterectomy)

  • participants allergic to any of the study medications (minoxidil, finasteride,spironolactone)

  • participants with other co-existing forms of alopecia (traction, alopecia areata, orscarring alopecias)

  • participants with obstructive uropathy or advanced liver disease

  • prior hair loss treatment within the last 6 months

  • hair loss from the chemotherapy or other medication-induced alopecia

  • Hair loss for greater than 5 years, as medical therapy is unlikely to have much effectat restoring hair follicles inactive for that long of a period.

Study Design

Study Start date:
August 01, 2016
Estimated Completion Date:
August 31, 2018

Study Description

Participants diagnosed with AGA will be randomized into one of the two treatment arms outlined below, and will take the assigned treatment for a total duration of 12 months. Medications will be dispensed by a nurse who is blinded to the participants within each treatment group. Global photograph assessment and participant questionnaires at 0, 4, 8 and 12 months will be the primary means to determine improvement in hair loss.

Compare the following interventions in treating postmenopausal female AGA:

A) Combination 5% Minoxidil and 200mg Spironolactone (Combination Group) B) 5mg Finasteride with placebo topical preparation (Single Group)

Connect with a study center

  • UF Health

    Gainesville, Florida 32610
    United States

    Site Not Available

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