Incretin-based Therapy in Preclinical Type 1 Diabetes in Adults

Last updated: January 7, 2022
Sponsor: University of Oulu
Overall Status: Active - Enrolling

Phase

2

Condition

Diabetes Prevention

Diabetes Mellitus, Type 1

Diabetes And Hypertension

Treatment

N/A

Clinical Study ID

NCT02611232
LiraAAB18-30
2014-003667-37
U1111-1176-6062
3-SRA-2014-301-M-R
  • Ages 18-30
  • All Genders

Study Summary

The main objectives of the trial are to study whether daily treatment with liraglutide improves insulin secretion and glucose metabolism, and whether liraglutide treatment is tolerable and safe in subjects with preclinical type 1 diabetes aged 18-30 years.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 18-30 years of age
  • positive for at least 2 biochemical islet autoantibodies
  • have normal glucose tolerance in OGTT
  • are not pregnant

Exclusion

Exclusion Criteria:

  • allergic to liraglutide or other ingredients of Victoza®
  • Type 1 diabetes
  • diabetic ketoacidosis
  • previous treatment in the last three months with any antidiabetic medication
  • impaired liver or kidney function or on dialysis
  • severe heart failure
  • severe stomach or gut problem resulting in gastroparesis, or inflammatory boweldisease
  • past or current history of pancreatitis
  • serum calcitonin value above normal (>50 ng/l or ≥3.4pmol/l)
  • presence of any chronic metabolic, hematologic or malignant disease
  • obesity BMI ≥30
  • pregnant females and females of childbearing potential who are not using adequatecontraceptive methods.
  • breast-feeding

Study Design

Total Participants: 42
Study Start date:
December 01, 2015
Estimated Completion Date:
June 30, 2024

Connect with a study center

  • University of Oulu and Oulu University Hospital

    Oulu, 90029
    Finland

    Site Not Available

  • University of Tampere and Tampere University Hospital

    Tampere, 33521
    Finland

    Site Not Available

  • University of Turku and Turku University Hospital

    Turku, 20520
    Finland

    Site Not Available

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