Emotional Lived in Patients Suffering From Psychogenic Nonepileptic Seizures : Study by Functional Magnetic Resonance Imaging

Last updated: March 13, 2024
Sponsor: Central Hospital, Nancy, France
Overall Status: Completed

Phase

N/A

Condition

Somatoform And Dissociative Disorders

Treatment

psychiatric evaluation

fMRI (functional Magnetic Resonance Imaging)

Clinical Study ID

NCT02976545
2016-A01295-46
  • Ages > 18
  • Female
  • Accepts Healthy Volunteers

Study Summary

Currently, hypothetical models of understanding Psychogenic Non-epileptic Seizures (PNES) involve emotional dysregulation.

The hypothesis of a disorder of emotional experience is mainly based on behavioral data and disturbance of autonomic responses in response to images in emotional content (Mignot et al 2015, in submission; Bakvis et al 2013). Various imaging studies have identified brain structures belonging to the limbic system in particular that seem functionally impaired in this population. These functional connectivity abnormalities are correlated with dissociation scores in PNES patients (Van der Kruijs et al 2012 and 2014).

Investigators propose to specifically study the brain activity of PNES patients during tasks emotional content to identify the mechanisms involved in this emotional dysregulation. This work is essential to understanding the mechanisms and the development of new therapeutic strategies

Eligibility Criteria

Inclusion

Common Inclusion Criteria:

  • Female,
  • Right-handed
  • Affiliation to the French social security system,
  • Informed signing of the study consent. Specific Inclusion Criteria for PNES group :
  • PNES diagnosed by a neurologist specialized in epilepsy, based on clinical symptomsanalysis and video-EEG recording,
  • Absence of concomitant epilepsy. Specific Inclusion Criteria for PTSD group : PTSD diagnosed by a psychiatrist, based onclinical symptoms as recorded in DSM5 (Diagnostic and Statistical Manual of MentalDisorders). Specific Inclusion Criteria for healthy controls : Healthy controls will be paired up withpatients on age and level of schooling criteria.

Exclusion

Exclusion Criteria: common criteria for all groups:

  • Neurological history or comorbidity (epilepsy included),
  • Current neurological treatment,
  • Posology change or introduction of psychoactive treatment dating back to less than amonth,
  • Psychotic comorbidity (schizophrenia),
  • Addiction history apart for smoking,
  • History of head trauma,
  • Mental retardation,
  • Being the subject of articles L.1121-5 to L.1121-8 and L1122-1-2 of the French Code ofPublic Health (i.e. being a not responsible adult),
  • Lack of French language proficiency or inability to understand instructions,
  • Uncorrected visual impairment,
  • Any contraindication to MRI (pacemaker, ferromagnetic foreign body, claustrophobia,etc.). Specific exclusion Criteria for PNES group : Diagnosis of PNES challenged or denied by thepatient. Specific exclusion Criteria for PTSD group :
  • Diagnosis of PTSD challenged or denied by the patient, current or history offunctional neurological symptom disorder,
  • History of PNES (conversion disorder). Specific exclusion Criteria for healthy controls :
  • History of PTSD,
  • History of PNES (conversion disorder).

Study Design

Total Participants: 68
Treatment Group(s): 2
Primary Treatment: psychiatric evaluation
Phase:
Study Start date:
October 03, 2017
Estimated Completion Date:
September 30, 2022

Connect with a study center

  • CHRU de Nancy

    Nancy, 54000
    France

    Site Not Available

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