Vasopressor Infusion in Cesarean Delivery

Last updated: September 22, 2021
Sponsor: Cairo University
Overall Status: Active - Recruiting

Phase

4

Condition

Anesthesia (Local)

Anesthesia

Treatment

N/A

Clinical Study ID

NCT03248791
N-86-2017
  • Ages 18-40
  • Female

Study Summary

Comparison will be conducted between continuous variable infusions of both drugs (Phenylephrine and Norepinephrine) with starting doses of 0.75 mcg/Kg/min and 0.1 mcg/Kg/min respectively for prophylaxis against Post-spinal hypotension during cesarean delivery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • full term
  • pregnant women
  • scheduled for cesarean section

Exclusion

Exclusion Criteria:

  • pre-ecpamsia
  • eclampsia
  • bleeding
  • cardiac dysfuction

Study Design

Total Participants: 120
Study Start date:
August 20, 2017
Estimated Completion Date:
March 10, 2022

Study Description

Maternal hypotension is a common complication after spinal anesthesia for cesarean delivery (CD). Many vasopressors have been used for prevention of post-spinal hypotension (PSH) during CD; however, the optimum protocol for prophylaxis is not established yet. Phenylephrine (PE) is a popular vasopressor used in obstetric anesthesia; however, its use is limited by its marked cardiac depressant nature. Norepinephrine (NE) is a potent vasopressor characterized by both α adrenergic agonistic activity in addition to a weak β adrenergic agonistic activity; thus, NE is considered a vasopressor with minimal cardiac depressant effect; these pharmacological properties would make NE an attractive alternative to PE. In this study, we will compare continuous variable infusion of both drugs (PE and NE) with doses of 0.75 mcg/Kg/min and 0.1 mcg/Kg/min respectively for prophylaxis against PSH during CD.

Connect with a study center

  • Cairo University

    Cairo,
    Egypt

    Active - Recruiting

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