Phase
Condition
Carcinoma
Head And Neck Cancer
Squamous Cell Carcinoma
Treatment
Laboratory Biomarker Analysis
Quality-of-Life Assessment
Intensity-Modulated Radiation Therapy
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
PRIOR TO STEP 1 REGISTRATION INCLUSION CRITERIA
Patients must have pathologically confirmed, previously untreated, unresectedsquamous cell carcinoma of the larynx, hypopharynx, oropharynx, oral cavity, orcarcinoma of unknown head/neck primary prior to step 1 registration; submission ofhematoxylin and eosin (H&E) stained slides and formalin-fixed and paraffin-embedded (FFPE) tissue block (or punch biopsy of FFPE block) to the biospecimen bank atUniversity of California, San Francisco (UCSF) for central review for oropharyngealand unknown primaries and for p16 analysis for all other non-oropharyngeal primariesis mandatory for all patients; investigators should check with their pathologydepartment regarding release of biospecimens before approaching patients aboutparticipation in the trial; for oropharyngeal and unknown primaries, submission ofH&E and p16 stained slides (with the required block for PD-L1) to the biospecimenbank at UCSF for central review is also required prior to step 2 registration
Note: fine needle aspirates (FNA) samples are not acceptable since they do notprovide enough material for PD-L1 and p16 testing; however, if a cell blockderived from the FNA is available, it is allowable if there are sufficientcells present in the block for PD-L1 testing; Dr. Jordan will determine thisupon receipt; for sites submitting FNA cell blocks for ALL patients they mustdo so within 7-10 business days from registering the patient; sites mustconfirm with their cytology/pathology labs to make sure they can provide therequired material as the bank must be able to retain these samples for themandatory testing
Patients must have locoregionally advanced head and neck squamous cell carcinoma (HNSCC)
For p16-positive oropharyngeal/unknown primaries, American Joint Committee onCancer [AJCC] 8th edition stage III and selected stage I-II based on smokingstatus in pack-years
For laryngeal, hypopharyngeal, and oral cavity primaries and p16-negativeoropharyngeal/unknown primaries, AJCC 8th edition stage III-IVB
Based on the following minimum diagnostic workup within 60 days prior to step 1registration:
General history and physical examination by a radiation oncologist ormedical oncologist or ear, nose and throat (ENT) or head & neck surgeon
For larynx, hypopharynx, and base of tongue primaries, alaryngopharyngoscopy (mirror and/or fiberoptic and/or direct procedure) isrequired, unless the patient cannot tolerate or refuses
Imaging of the head and neck with a neck CT or magnetic resonance imaging (MRI) (with contrast, unless contraindicated) or PET/CT; note that the CT portion ofthe PET/CT must be of diagnostic quality, including contrast administrationunless contraindicated. If the CT portion of the PET/CT study is low-dose (non-diagnostic), then an additional CT or MRI study with contrast (unlesscontraindicated) is required
Chest imaging: chest CT with and without contrast (unless contraindicated) orPET/CT
Patients must have a contraindication to cisplatin as defined in the followingbullet points; sites must complete the online tool at comogram.org prior to step 1registration to determine if the patient is eligible; the scores must be recorded ona case report form (CRF)
Age >= 70 with moderate to severe comorbidity or vulnerability to cisplatin,defined as having one or more of the following conditions within 30 days priorto step 1 registration:
Modified Charlson Comorbidity Index >= 1
Adult Comorbidity Evaluation (ACE)-27 Index >= 1
Generalized Competing Event Model for Cancer Risk (GCE) omega PFS score < 0.80
Geriatric screening (G-8) score =< 14
Cancer and Aging Research Group (CARG) toxicity score >= 30%
Cumulative Illness Rating scale for Geriatrics (CIRS-G) score >= 4 OR
Age < 70 with severe comorbidity or vulnerability to cisplatin, defined ashaving two or more of the following conditions within 30 days prior to step 1registration
Modified Charlson Comorbidity Index >= 1
ACE-27 Index >= 1
GCE omega PFS-score < 0.80
G-8 score =< 14
CARG Toxicity score >= 30%
CIRS-G score >= 4 OR
Age >= 18 with an absolute or relative contraindication to cisplatin, definedas one or more of the following within 30 days prior to step 1 registration:
Creatinine clearance (CC) > 30 and < 60 cc/min; for this calculation, usethe Cockcroft-Gault formula
Zubrod performance status 2 prior to step 1 registration
Pre-existing peripheral neuropathy grade >= 1
History of hearing loss, defined as either:
Existing need of a hearing aid OR
>= 25 decibel shift over 2 contiguous frequencies on a pretreatmenthearing test as clinically indicated
Absolute neutrophil count (ANC) >= 1,000 cells/mm^3 (within 14 days prior to step 1registration)
Platelets >= 100,000 cells/mm^3 (within 14 days prior to step 1 registration)
Hemoglobin >= 9.0 g/dl (Note: the use of transfusion or other intervention toachieve hemoglobin [Hgb] >= 9.0 g/dl is acceptable) (within 14 days prior to step 1registration)
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 timesinstitutional upper limit of normal (within 14 days prior to step 1 registration)
Serum bilirubin =< 1.5 x institutional upper limit of normal (within 14 days priorto step 1 registration)
Measured creatinine clearance (CL) > 30 mL/min or calculated creatinine CL > 30mL/min by the Cockcroft-Gault formula (Cockcroft and Gault 1976) or by 24-hour urinecollection for determination of creatinine clearance (within 14 days prior to step 1registration)
For women of childbearing potential, a negative serum or urine pregnancy test within 14 days prior to step 1 registration; Note: women will be considered post-menopausalif they have been amenorrheic for 12 months without an alternative medical cause;the following age-specific requirements apply:
Women < 50 years of age would be considered post-menopausal if they have beenamenorrheic for 12 months or more following cessation of exogenous hormonaltreatments and if they have luteinizing hormone and follicle-stimulatinghormone levels in the post-menopausal range for the institution or underwentsurgical sterilization (bilateral oophorectomy or hysterectomy)
Women >= 50 years of age would be considered post-menopausal if they have beenamenorrheic for 12 months or more following cessation of all exogenous hormonaltreatments, had radiation-induced menopause with last menses > 1 year ago, hadchemotherapy-induced menopause with last menses > 1 year ago, or underwentsurgical sterilization (bilateral oophorectomy, bilateral salpingectomy orhysterectomy)
The patient or a legally authorized representative must provide study-specificinformed consent prior to step 1 registration
PRIOR TO STEP 2 REGISTRATION INCLUSION CRITERIA
For patients with oropharyngeal or unknown primaries: p16 determination byimmunohistochemistry (defined as greater than 70% strong nuclear or nuclear andcytoplasmic staining of tumor cells), confirmed by central pathology review
Note: for patients with oral cavity, laryngeal, and hypopharyngeal primaries,analysis of p16 status prior to step 2 registration/randomization is notrequired (p16 status will be analyzed centrally post-hoc); step 2 registrationfor these patients can be completed after step 1 registration
Exclusion
Exclusion Criteria:
PRIOR TO STEP 1 REGISTRATION EXCLUSION CRITERIA
Prior invasive malignancy within the past 3 years (except for non-melanomatous skincancer, and early stage treated prostate cancer); synchronous head and neckprimaries are ineligible
Prior radiotherapy to the region of the study cancer that would result in overlap ofradiation therapy fields
Note: Prior external beam radiotherapy is excluded, but iodine 131 is allowed
Prior immunotherapy
Prior systemic therapy, including cytotoxic chemotherapy, biologic/targeted therapy,or immune therapy for the study cancer
Major surgery within 28 days prior to step 1 registration
Proven evidence of distant metastases
If both of the following conditions are present, the patient is ineligible:
=< 10 pack-year smoking history
p16-positive carcinoma of the oropharynx or unknown primary that are T0-3, N0-1 (AJCC 8th Edition)
Note: in the event that a registered patient with =< 10 pack-years has ap16-positive result on central review with the tumor and nodal stage T0-3,N0-1 (AJCC 8th Edition), then the site will be notified that the patientis ineligible
Zubrod performance status >= 3
Body weight =< 30 kg
Patients with oral cavity cancer are excluded from participation if the patient ismedically operable and resection of the primary tumor is considered technicallyfeasible by an oral or head and neck cancers surgical subspecialist;(please consultthe surgical oncology co-principal investigator [PI], Steven Chang, Doctor ofMedicine [MD], if clarification is needed on an individual case)
Sodium < 130 mmol/L or > 155 mmol/L (within 14 days of step 1 registration, unlesscorrected prior to step 1 registration)
Potassium < 3.5 mmol/L or > 6 mmol/L (within 14 days of step 1 registration, unlesscorrected prior to step 1 registration)
Fasting glucose < 40 mg/dl or > 400 mg/dl (within 14 days of step 1 registration,unless corrected prior to step 1 registration)
Serum calcium (ionized or adjusted for albumin) < 7 mg/dl or > 12.5 mg/dl (within 14days of step 1 registration, unless corrected prior to step 1 registration)
Magnesium < 0.9 mg/dl or > 3 mg/dl (within 14 days of step 1 registration, unlesscorrected prior to step 1 registration)
Unstable angina and/or congestive heart failure requiring hospitalization within 3months prior to step 1 registration
Transmural myocardial infarction within 3 months prior to step 1 registration
Respiratory illness requiring hospitalization at the time of step 1 registration
Note: if the respiratory illness is resolved and the patient meets theeligibility status above, then the patient can be considered for the trial
Idiopathic pulmonary fibrosis or other severe interstitial lung disease thatrequires oxygen therapy or is thought to require oxygen therapy within 1 year priorto step 1 registration
History of (non-infectious) pneumonitis that required steroids or currentpneumonitis
Clinically apparent jaundice and/or known coagulation defects
Active or prior documented autoimmune or inflammatory disorders (includinginflammatory bowel disease [e.g., colitis or Crohn's disease], diverticulitis [withthe exception of diverticulosis], systemic lupus erythematosus, Sarcoidosissyndrome, or Wegener syndrome [granulomatosis with polyangiitis], Graves' disease,rheumatoid arthritis, hypophysitis, uveitis, etc.)
The following are exceptions to this criterion:
Patients with vitiligo or alopecia;
Patients with hypothyroidism (e.g., following Hashimoto syndrome) stableon hormone replacement;
Any chronic skin condition that does not require systemic therapy;
Patients without active disease in the last 5 years may be included butonly after consultation with the medical oncology study chair;
Patients with celiac disease controlled by diet alone
History of active primary immunodeficiency including, but not limited to acquiredimmune deficiency syndrome (AIDS) based upon current Centers for Disease Control andPrevention (CDC) definition; Note: human immunodeficiency virus (HIV) testing is notrequired for entry into this protocol; the need to exclude patients with AIDS fromthis protocol is necessary because the treatment involved in this protocol may beimmunosuppressive; patients with known HIV, CD4 counts >= 200/uL, and undetectableviral loads who are stable on an antiretroviral regimen may be included
Current or prior use of immunosuppressive medication within 14 days before step 1registration, with the exceptions of intranasal and inhaled corticosteroids orsystemic corticosteroids at physiological doses, which are not to exceed 10 mg/dayof prednisone, or an equivalent corticosteroid
Receipt of live attenuated vaccination within 30 days prior to step 1 registration
Medical or psychiatric illness which would compromise the patient's ability totolerate treatment or limit compliance with study requirements
Pregnancy or women of childbearing potential and men who are sexually active and notwilling/able to use medically acceptable forms of contraception during treatment andfor 6 months after the last dose of cetuximab or MEDI14736 (durvalumab); thisexclusion is necessary because the treatment involved in this study may besignificantly teratogenic; women who are breastfeeding are also excluded
Prior allergic reaction or hypersensitivity to cetuximab or MEDI4736 (durvalumab) orany of study drug excipients
History of allogenic organ transplantation
Uncontrolled hypertension
Uncontrolled cardiac arrhythmia
Uncontrolled serious chronic gastrointestinal condition associated with diarrhea
Active infection including tuberculosis (clinical evaluation that includes clinicalhistory, physical examination and radiographic findings, and tuberculosis [TB]testing in line with local practice), hepatitis B (known positive hepatitis B virus [HBV] surface antigen [HBsAg] result), hepatitis C; patients with a past or resolvedHBV infection (defined as the presence of hepatitis B core antibody [anti-HBc] andabsence of HBsAg) are eligible; patients positive for hepatitis C (hepatitis C virus [HCV]) antibody are eligible only if polymerase chain reaction is negative for HCVribonucleic acid (RNA)
Study Design
Study Description
Connect with a study center
London Regional Cancer Program
London, Ontario N6A 4L6
CanadaSite Not Available
University Health Network-Princess Margaret Hospital
Toronto, Ontario M5G 2M9
CanadaSite Not Available
The Research Institute of the McGill University Health Centre (MUHC)
Montreal, Quebec H3H 2R9
CanadaSite Not Available
Allan Blair Cancer Centre
Regina, Saskatchewan S4T 7T1
CanadaSite Not Available
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233
United StatesSite Not Available
University of South Alabama Mitchell Cancer Institute
Mobile, Alabama 36688
United StatesSite Not Available
Banner MD Anderson Cancer Center
Gilbert, Arizona 85234
United StatesSite Not Available
CTCA at Western Regional Medical Center
Goodyear, Arizona 85338
United StatesSite Not Available
Banner University Medical Center - Tucson
Tucson, Arizona 85719
United StatesSite Not Available
University of Arizona Cancer Center-North Campus
Tucson, Arizona 85719
United StatesSite Not Available
Kaiser Permanente-Deer Valley Medical Center
Antioch, California 94531
United StatesSite Not Available
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California 95603
United StatesSite Not Available
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California 94704
United StatesSite Not Available
City of Hope Comprehensive Cancer Center
Duarte, California 91010
United StatesSite Not Available
Kaiser Permanente Dublin
Dublin, California 94568
United StatesSite Not Available
Kaiser Permanente-Fremont
Fremont, California 94538
United StatesSite Not Available
Fresno Cancer Center
Fresno, California 93720
United StatesSite Not Available
Kaiser Permanente-Fresno
Fresno, California 93720
United StatesSite Not Available
UC San Diego Moores Cancer Center
La Jolla, California 92093
United StatesSite Not Available
Cedars Sinai Medical Center
Los Angeles, California 90048
United StatesSite Not Available
Kaiser Permanente-Modesto
Modesto, California 95356
United StatesSite Not Available
Kaiser Permanente Oakland-Broadway
Oakland, California 94611
United StatesSite Not Available
Kaiser Permanente-Oakland
Oakland, California 94611
United StatesSite Not Available
Stanford Cancer Institute Palo Alto
Palo Alto, California 94304
United StatesSite Not Available
VA Palo Alto Health Care System
Palo Alto, California 94304
United StatesSite Not Available
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California 95670
United StatesSite Not Available
Kaiser Permanente-Richmond
Richmond, California 94801
United StatesSite Not Available
Rohnert Park Cancer Center
Rohnert Park, California 94928
United StatesSite Not Available
Kaiser Permanente-Roseville
Roseville, California 95661
United StatesSite Not Available
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California 95661
United StatesSite Not Available
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California 95678
United StatesSite Not Available
Kaiser Permanente Downtown Commons
Sacramento, California 95814
United StatesSite Not Available
Kaiser Permanente-South Sacramento
Sacramento, California 95823
United StatesSite Not Available
South Sacramento Cancer Center
Sacramento, California 95823
United StatesSite Not Available
Sutter Medical Center Sacramento
Sacramento, California 95816
United StatesSite Not Available
University of California Davis Comprehensive Cancer Center
Sacramento, California 95817
United StatesSite Not Available
Kaiser Permanente-San Francisco
San Francisco, California 94115
United StatesSite Not Available
UCSF Medical Center-Mission Bay
San Francisco, California 94158
United StatesSite Not Available
UCSF Medical Center-Mount Zion
San Francisco, California 94115
United StatesSite Not Available
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California 95119
United StatesSite Not Available
Kaiser Permanente San Leandro
San Leandro, California 94577
United StatesSite Not Available
Kaiser San Rafael-Gallinas
San Rafael, California 94903
United StatesSite Not Available
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California 95051
United StatesSite Not Available
Kaiser Permanente-Santa Rosa
Santa Rosa, California 95403
United StatesSite Not Available
City of Hope South Pasadena
South Pasadena, California 91030
United StatesSite Not Available
Kaiser Permanente Cancer Treatment Center
South San Francisco, California 94080
United StatesSite Not Available
Kaiser Permanente-South San Francisco
South San Francisco, California 94080
United StatesSite Not Available
Kaiser Permanente-Stockton
Stockton, California 95210
United StatesSite Not Available
Torrance Memorial Medical Center
Torrance, California 90509
United StatesSite Not Available
Torrance Memorial Physician Network - Cancer Care
Torrance, California 90505
United StatesSite Not Available
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California 96161
United StatesSite Not Available
Kaiser Permanente Medical Center-Vacaville
Vacaville, California 95688
United StatesSite Not Available
Kaiser Permanente-Vallejo
Vallejo, California 94589
United StatesSite Not Available
Kaiser Permanente-Walnut Creek
Walnut Creek, California 94596
United StatesSite Not Available
UCHealth University of Colorado Hospital
Aurora, Colorado 80045
United StatesSite Not Available
University of Colorado Hospital
Aurora, Colorado 80045
United StatesSite Not Available
Memorial Hospital North
Colorado Springs, Colorado 80920
United StatesSite Not Available
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado 80907
United StatesSite Not Available
UCHealth Memorial Hospital Central
Colorado Springs, Colorado 80909
United StatesSite Not Available
Poudre Valley Hospital
Fort Collins, Colorado 80524
United StatesSite Not Available
Banner McKee Medical Center
Loveland, Colorado 80539
United StatesSite Not Available
McKee Medical Center
Loveland, Colorado 80539
United StatesSite Not Available
Smilow Cancer Hospital-Hamden Care Center
Hamden, Connecticut 06518
United StatesSite Not Available
Yale University
New Haven, Connecticut 06520
United StatesSite Not Available
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut 06611
United StatesSite Not Available
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut 06385
United StatesSite Not Available
Beebe South Coastal Health Campus
Frankford, Delaware 19945
United StatesSite Not Available
Beebe South Coastal Health Campus
Millville, Delaware 19967
United StatesSite Not Available
Helen F Graham Cancer Center
Newark, Delaware 19713
United StatesSite Not Available
Beebe Health Campus
Rehoboth Beach, Delaware 19971
United StatesSite Not Available
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida 33146
United StatesSite Not Available
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida 33442
United StatesSite Not Available
Baptist MD Anderson Cancer Center
Jacksonville, Florida 32207
United StatesSite Not Available
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida 33136
United StatesSite Not Available
Moffitt Cancer Center
Tampa, Florida 33612
United StatesSite Not Available
Emory University Hospital Midtown
Atlanta, Georgia 30308
United StatesSite Not Available
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia 30322
United StatesSite Not Available
Grady Health System
Atlanta, Georgia 30303
United StatesSite Not Available
Augusta University Medical Center
Augusta, Georgia 30912
United StatesSite Not Available
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii 96813
United StatesSite Not Available
Queen's Medical Center
Honolulu, Hawaii 96813
United StatesSite Not Available
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii 96817
United StatesSite Not Available
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
United StatesSite Not Available
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho 83687
United StatesSite Not Available
John H Stroger Jr Hospital of Cook County
Chicago, Illinois 60612
United StatesSite Not Available
Northwestern University
Chicago, Illinois 60611
United StatesSite Not Available
Rush University Medical Center
Chicago, Illinois 60612
United StatesSite Not Available
University of Illinois
Chicago, Illinois 60612
United StatesSite Not Available
Decatur Memorial Hospital
Decatur, Illinois 62526
United StatesSite Not Available
Crossroads Cancer Center
Effingham, Illinois 62401
United StatesSite Not Available
Western Illinois Cancer Treatment Center
Galesburg, Illinois 61401
United StatesSite Not Available
Methodist Medical Center of Illinois
Peoria, Illinois 61636
United StatesSite Not Available
OSF Saint Francis Medical Center
Peoria, Illinois 61637
United StatesSite Not Available
Memorial Medical Center
Springfield, Illinois 62781
United StatesSite Not Available
Springfield Memorial Hospital
Springfield, Illinois 62781
United StatesSite Not Available
Carle Cancer Center
Urbana, Illinois 61801
United StatesSite Not Available
IU Health North Hospital
Carmel, Indiana 46032
United StatesSite Not Available
Parkview Hospital Randallia
Fort Wayne, Indiana 46805
United StatesSite Not Available
Parkview Regional Medical Center
Fort Wayne, Indiana 46845
United StatesSite Not Available
Community Cancer Center East
Indianapolis, Indiana 46219
United StatesSite Not Available
Community Cancer Center North
Indianapolis, Indiana 46256
United StatesSite Not Available
Community Cancer Center South
Indianapolis, Indiana 46227
United StatesSite Not Available
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana 46202
United StatesSite Not Available
Sidney and Lois Eskenazi Hospital
Indianapolis, Indiana 46202
United StatesSite Not Available
Mercy Cancer Center-West Lakes
Clive, Iowa 50325
United StatesSite Not Available
Iowa Methodist Medical Center
Des Moines, Iowa 50309
United StatesSite Not Available
Mercy Medical Center - Des Moines
Des Moines, Iowa 50314
United StatesSite Not Available
University of Kansas Cancer Center
Kansas City, Kansas 66160
United StatesSite Not Available
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas 66210
United StatesSite Not Available
Salina Regional Health Center
Salina, Kansas 67401
United StatesSite Not Available
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas 66205
United StatesSite Not Available
Ascension Via Christi Hospitals Wichita
Wichita, Kansas 67214
United StatesSite Not Available
University of Kentucky/Markey Cancer Center
Lexington, Kentucky 40536
United StatesSite Not Available
Norton Brownsboro Hospital and Medical Campus
Louisville, Kentucky 40241
United StatesSite Not Available
Norton Hospital Pavilion and Medical Campus
Louisville, Kentucky 40202
United StatesSite Not Available
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky 40202
United StatesSite Not Available
East Jefferson General Hospital
Metairie, Louisiana 70006
United StatesSite Not Available
Greater Baltimore Medical Center
Baltimore, Maryland 21204
United StatesSite Not Available
Boston Medical Center
Boston, Massachusetts 02118
United StatesSite Not Available
Lahey Hospital and Medical Center
Burlington, Massachusetts 01805
United StatesSite Not Available
Saint Joseph Mercy Hospital
Ann Arbor, Michigan 48106
United StatesSite Not Available
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
United StatesSite Not Available
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan 48109
United StatesSite Not Available
McLaren Cancer Institute-Bay City
Bay City, Michigan 48706
United StatesSite Not Available
Saint Joseph Mercy Brighton
Brighton, Michigan 48114
United StatesSite Not Available
Trinity Health Medical Center - Brighton
Brighton, Michigan 48114
United StatesSite Not Available
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan 48183
United StatesSite Not Available
Saint Joseph Mercy Canton
Canton, Michigan 48188
United StatesSite Not Available
Trinity Health Medical Center - Canton
Canton, Michigan 48188
United StatesSite Not Available
Chelsea Hospital
Chelsea, Michigan 48118
United StatesSite Not Available
Saint Joseph Mercy Chelsea
Chelsea, Michigan 48118
United StatesSite Not Available
McLaren Cancer Institute-Clarkston
Clarkston, Michigan 48346
United StatesSite Not Available
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan 48038
United StatesSite Not Available
Henry Ford Hospital
Detroit, Michigan 48202
United StatesSite Not Available
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan 48201
United StatesSite Not Available
Weisberg Cancer Treatment Center
Farmington Hills, Michigan 48334
United StatesSite Not Available
McLaren Cancer Institute-Flint
Flint, Michigan 48532
United StatesSite Not Available
Singh and Arora Hematology Oncology PC
Flint, Michigan 48532
United StatesSite Not Available
Allegiance Health
Jackson, Michigan 49201
United StatesSite Not Available
Karmanos Cancer Institute at McLaren Greater Lansing
Lansing, Michigan 48910
United StatesSite Not Available
Mid-Michigan Physicians-Lansing
Lansing, Michigan 48912
United StatesSite Not Available
Sparrow Hospital
Lansing, Michigan 48912
United StatesSite Not Available
University of Michigan Health - Sparrow Lansing
Lansing, Michigan 48912
United StatesSite Not Available
McLaren Cancer Institute-Lapeer Region
Lapeer, Michigan 48446
United StatesSite Not Available
McLaren Cancer Institute-Macomb
Mount Clemens, Michigan 48043
United StatesSite Not Available
McLaren Cancer Institute-Northern Michigan
Petoskey, Michigan 49770
United StatesSite Not Available
McLaren-Port Huron
Port Huron, Michigan 48060
United StatesSite Not Available
Ascension Saint Mary's Hospital
Saginaw, Michigan 48601
United StatesSite Not Available
MyMichigan Medical Center Saginaw
Saginaw, Michigan 48601
United StatesSite Not Available
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan 48322
United StatesSite Not Available
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
United StatesSite Not Available
Fairview Ridges Hospital
Burnsville, Minnesota 55337
United StatesSite Not Available
Miller-Dwan Hospital
Duluth, Minnesota 55805
United StatesSite Not Available
Fairview Southdale Hospital
Edina, Minnesota 55435
United StatesSite Not Available
Unity Hospital
Fridley, Minnesota 55432
United StatesSite Not Available
Hennepin County Medical Center
Minneapolis, Minnesota 55415
United StatesSite Not Available
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United StatesSite Not Available
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
United StatesSite Not Available
Regions Hospital
Saint Paul, Minnesota 55101
United StatesSite Not Available
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United StatesSite Not Available
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
United StatesSite Not Available
Mercy Hospital Saint Louis
Saint Louis, Missouri 63141
United StatesSite Not Available
Washington University School of Medicine
Saint Louis, Missouri 63110
United StatesSite Not Available
Siteman Cancer Center at Saint Peters Hospital
Saint Peters, Missouri 63376
United StatesSite Not Available
Billings Clinic Cancer Center
Billings, Montana 59101
United StatesSite Not Available
Kalispell Regional Medical Center
Kalispell, Montana 59901
United StatesSite Not Available
Logan Health Medical Center
Kalispell, Montana 59901
United StatesSite Not Available
CHI Health Saint Francis
Grand Island, Nebraska 68803
United StatesSite Not Available
Nebraska Cancer Specialists/Oncology Hematology West PC
Grand Island, Nebraska 68803
United StatesSite Not Available
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire 03756
United StatesSite Not Available
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
United StatesSite Not Available
Hackensack University Medical Center
Hackensack, New Jersey 07601
United StatesSite Not Available
Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
United StatesSite Not Available
Memorial Sloan Kettering Bergen
Montvale, New Jersey 07645
United StatesSite Not Available
New Mexico Oncology Hematology Consultants
Albuquerque, New Mexico 87109
United StatesSite Not Available
University of New Mexico Cancer Center
Albuquerque, New Mexico 87106
United StatesSite Not Available
James J Peters VA Medical Center
Bronx, New York 10468
United StatesSite Not Available
Montefiore Medical Center - Moses Campus
Bronx, New York 10467
United StatesSite Not Available
Roswell Park Cancer Institute
Buffalo, New York 14263
United StatesSite Not Available
Memorial Sloan Kettering Commack
Commack, New York 11725
United StatesSite Not Available
Memorial Sloan Kettering Westchester
Harrison, New York 10604
United StatesSite Not Available
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York 10016
United StatesSite Not Available
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United StatesSite Not Available
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York 10032
United StatesSite Not Available
University of Rochester
Rochester, New York 14642
United StatesSite Not Available
Stony Brook University Medical Center
Stony Brook, New York 11794
United StatesSite Not Available
State University of New York Upstate Medical University
Syracuse, New York 13210
United StatesSite Not Available
Memorial Sloan Kettering Nassau
Uniondale, New York 11553
United StatesSite Not Available
Atrium Health Stanly/LCI-Albemarle
Albemarle, North Carolina 28002
United StatesSite Not Available
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
United StatesSite Not Available
Atrium Health Pineville/LCI-Pineville
Charlotte, North Carolina 28210
United StatesSite Not Available
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina 28203
United StatesSite Not Available
Atrium Health Cabarrus/LCI-Concord
Concord, North Carolina 28025
United StatesSite Not Available
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina 28791
United StatesSite Not Available
Atrium Health Union/LCI-Union
Monroe, North Carolina 28112
United StatesSite Not Available
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
United StatesSite Not Available
Aultman Health Foundation
Canton, Ohio 44710
United StatesSite Not Available
Cleveland Clinic Mercy Hospital
Canton, Ohio 44708
United StatesSite Not Available
Geauga Hospital
Chardon, Ohio 44024
United StatesSite Not Available
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio 45219
United StatesSite Not Available
Case Western Reserve University
Cleveland, Ohio 44106
United StatesSite Not Available
Cleveland Clinic Foundation
Cleveland, Ohio 44195
United StatesSite Not Available
MetroHealth Medical Center
Cleveland, Ohio 44109
United StatesSite Not Available
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United StatesSite Not Available
Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio 44906
United StatesSite Not Available
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor, Ohio 44060
United StatesSite Not Available
North Coast Cancer Care
Sandusky, Ohio 44870
United StatesSite Not Available
ProMedica Flower Hospital
Sylvania, Ohio 43560
United StatesSite Not Available
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio 45069
United StatesSite Not Available
UHHS-Westlake Medical Center
Westlake, Ohio 44145
United StatesSite Not Available
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio 44691
United StatesSite Not Available
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United StatesSite Not Available
Good Samaritan Hospital
Corvallis, Oregon 97330
United StatesSite Not Available
Kaiser Permanente Northwest
Portland, Oregon 97227
United StatesSite Not Available
Providence Portland Medical Center
Portland, Oregon 97213
United StatesSite Not Available
Providence Saint Vincent Medical Center
Portland, Oregon 97225
United StatesSite Not Available
Jefferson Abington Hospital
Abington, Pennsylvania 19001
United StatesSite Not Available
Crozer-Keystone Regional Cancer Center at Broomall
Broomall, Pennsylvania 19008
United StatesSite Not Available
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania 19317
United StatesSite Not Available
Geisinger Medical Center
Danville, Pennsylvania 17822
United StatesSite Not Available
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania 17033-0850
United StatesSite Not Available
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania 17837
United StatesSite Not Available
Lewistown Hospital
Lewistown, Pennsylvania 17044
United StatesSite Not Available
Forbes Hospital
Monroeville, Pennsylvania 15146
United StatesSite Not Available
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
United StatesSite Not Available
Temple University Hospital
Philadelphia, Pennsylvania 19140
United StatesSite Not Available
Allegheny General Hospital
Pittsburgh, Pennsylvania 15212
United StatesSite Not Available
UPMC-Shadyside Hospital
Pittsburgh, Pennsylvania 15232
United StatesSite Not Available
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania 18840
United StatesSite Not Available
Reading Hospital
West Reading, Pennsylvania 19611
United StatesSite Not Available
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania 15090
United StatesSite Not Available
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania 18711
United StatesSite Not Available
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania 19090
United StatesSite Not Available
Medical University of South Carolina
Charleston, South Carolina 29425
United StatesSite Not Available
Gibbs Cancer Center-Pelham
Greer, South Carolina 29651
United StatesSite Not Available
Rock Hill Radiation Therapy Center
Rock Hill, South Carolina 29730
United StatesSite Not Available
Spartanburg Medical Center
Spartanburg, South Carolina 29303
United StatesSite Not Available
Avera Cancer Institute
Sioux Falls, South Dakota 57105
United StatesSite Not Available
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota 57117-5134
United StatesSite Not Available
M D Anderson Cancer Center
Houston, Texas 77030
United StatesSite Not Available
Dartmouth Cancer Center - North
Saint Johnsbury, Vermont 05819
United StatesSite Not Available
Norris Cotton Cancer Center-North
Saint Johnsbury, Vermont 05819
United StatesSite Not Available
University of Virginia Cancer Center
Charlottesville, Virginia 22908
United StatesSite Not Available
Sentara Norfolk General Hospital
Norfolk, Virginia 23507
United StatesSite Not Available
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
United StatesSite Not Available
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia 23298
United StatesSite Not Available
University of Washington Medical Center - Montlake
Seattle, Washington 98195
United StatesSite Not Available
West Virginia University Healthcare
Morgantown, West Virginia 26506
United StatesSite Not Available
Langlade Hospital and Cancer Center
Antigo, Wisconsin 54409
United StatesSite Not Available
Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
United StatesSite Not Available
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin 54301
United StatesSite Not Available
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin 54303
United StatesSite Not Available
UW Cancer Center Johnson Creek
Johnson Creek, Wisconsin 53038
United StatesSite Not Available
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek, Wisconsin 53038
United StatesSite Not Available
University of Wisconsin Carbone Cancer Center Johnson Creek
Johnson Creek, Wisconsin 53038
United StatesSite Not Available
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
United StatesSite Not Available
Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
United StatesSite Not Available
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin 53792
United StatesSite Not Available
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin 53792
United StatesSite Not Available
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
United StatesSite Not Available
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin 53051
United StatesSite Not Available
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin 53215
United StatesSite Not Available
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United StatesSite Not Available
Zablocki Veterans Administration Medical Center
Milwaukee, Wisconsin 53295
United StatesSite Not Available
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
United StatesSite Not Available
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
United StatesSite Not Available
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
United StatesSite Not Available
Aurora Medical Center in Summit
Summit, Wisconsin 53066
United StatesSite Not Available
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
United StatesSite Not Available
Aspirus Regional Cancer Center
Wausau, Wisconsin 54401
United StatesSite Not Available
Aurora West Allis Medical Center
West Allis, Wisconsin 53227
United StatesSite Not Available
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin 53095
United StatesSite Not Available
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