Antibiotic Irrigations for Intra-Abdominal Drains

Last updated: June 5, 2019
Sponsor: Paolo Goffredo
Overall Status: Active - Recruiting

Phase

2

Condition

Intra-abdominal Infections

Treatment

N/A

Clinical Study ID

NCT03476941
201703759
  • Ages 18-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Intra-abdominal abscesses are pus-filled pouches in the abdominal cavity. Current standard of care includes drain placement in the abscess cavity to reach source control as well as administration of systemic antibiotics. It is common practice to flush the drain on a daily basis to ensure patency. This study aims to analyze the clinical impact of a higher local concentration of antibiotics (rather than normal saline) provided through drain irrigation with an antimicrobial agent (Gentamicin and/or Clindamycin) compare to normal saline.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Intra-abdominal abscess drained with catheter/drain

  • Treatment with systemic antibiotics

  • Able to consent

Exclusion

Exclusion Criteria:

  • Abscess(es) not amendable for an image guided drain placement.

Study Design

Total Participants: 50
Study Start date:
April 01, 2019
Estimated Completion Date:
September 01, 2021

Study Description

People with an abdominal abscess who undergo drain placement will have those drains irrigated twice/day with either normal saline (placebo group) or with the above antibiotic solution for a total of 7 days or less if the drain were to be removed earlier. Outcomes of interest are duration of systemic antibiotics, and WBC and temperature curve.

Connect with a study center

  • The University of Iowa

    Iowa City, Iowa 52242
    United States

    Active - Recruiting

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