A Trial of Linaclotide 290 μg in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

Inclusion Criteria:

• Patient has no clinically significant findings on a physical examination and clinicallaboratory tests
• Female patients of childbearing potential must agree to use one of the followingmethods of birth control:

1. Hormonal contraception
2. Double-barrier birth control
3. Maintenance of a monogamous relationship with a male partner who has beensurgically sterilized by vasectomy

• Patient meets protocol criteria for diagnosis of IBS-C
• Patient demonstrates continued IBS-C symptoms through Pretreatment Period
• Patient maintains a minimum level of compliance with daily diary

Exclusion Criteria:

• Patient has history of loose or watery stools
• Patient has symptoms of or been diagnosed with a medical condition that may contributeto abdominal pain
• Patient has a structural abnormality of the gastrointestinal (GI) tract or a diseaseor condition that can affect GI motility
• Patient has any protocol-excluded or clinically significant medical or surgicalhistory that could confound the study assessments