Anogenital Distance Differences Between Transgender Males and Female Individuals

Last updated: March 31, 2019
Sponsor: Uludag University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT03789331
UU-SUAM-2017-21/37
  • Ages 18-50
  • Female
  • Accepts Healthy Volunteers

Study Summary

This study evaluates the anogenital distance measurement differences between transgender male individuals and normal healthy female individuals. Half of the participants will be selected from the men with a masculine gender identity who were assigned female sex at birth (Woman who wanted to be a man). Transgender men will be evaluated with the vaginal examination, and anogenital distance will be measured at the time of gynecological medico-legal evaluation before the sex reassignment surgery. While the other half of the participants will be selected from healthy female individuals, ordinary healthy women will be selected from patients who come to the gynecology clinic for another reason (Women with normal sexual orientation).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Individuals who are 18-50 years old.

  • Healthy transgender male individuals whose gender identity (Male) are different fromtheir birth-assigned sex (Female). The participants will be invited to the study atthe time of medico-legal evaluation before the sex reassignment surgery.

Exclusion

Exclusion Criteria:

  • Individuals who are older than 50 (People older than 50 cannot change their genderlegally in Turkey).

  • Other sexual orientation disorders. (Lesbian, Gay, Bisexual, Queer, Intersex, orAsexual persons)

Study Design

Total Participants: 150
Study Start date:
April 01, 2019
Estimated Completion Date:
March 15, 2020

Study Description

There is considerable evidence in human beings and in animal models supporting that anogenital distance as a sensitive biomarker of prenatal androgen reflection of reproductive health and sexual orientation. Anogenital distance is approximately twice as long in male animals compared to female animals, and it is routinely used to determine the natal or birth-assigned sex.

Studies have shown alterations in anogenital distance associated with reproductive health and sexual orientation. For instance, shorter anogenital distance has been reported in boys with hypospadias and cryptorchidism. Men with reduced testicular volume have significantly shorter anogenital distance compared with controls. Increased anogenital distance has been indicated in girls with congenital adrenal hyperplasia.

The investigators hypothesized that a prenatal pathological androgenic environment, resulting in a longer anogenital distance, will be able to be associated with a higher risk of sexual orientation disorders like transsexualism. This cross-sectional study aimed to assess the anogenital distance measurement differences between transgender male persons and normal healthy female individuals.

Connect with a study center

  • Uludag University Hospital, Department of Obstetrics and Gynecology

    Bursa, Ozluce 16059
    Turkey

    Active - Recruiting

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