Study to Evaluate the Safety and Efficacy of the Cytrellis Micro-Coring Device for the Treatment of Moderate to Severe Facial Wrinkles

Inclusion Criteria:

• Males and females 40-70 years of age

• Fitzpatrick Skin Type I to IV as judged by the Investigator

• Cheek areas are at least a score of 3 using the Lemperle Wrinkle Assessment Scale asjudged by the Investigator

• Able to provide written informed consent, understand and willing to comply with allstudy related procedures and follow-up visits.

Exclusion Criteria:

• Lesions suspicious for any malignancy or the presence of actinic keratosis, melasma,vitiligo, cutaneous papules/nodules or active inflammatory lesions in the areas to betreated

• History of keloid formation or hypertrophic scarring

• History of trauma or surgery to the treatment areas in the past 6 months

• Scar present in the areas to be treated

• Silicone injections in the areas to be treated

• Injection of dermal fillers, fat or botulinum toxin, as well as any minimallyinvasive/invasive medical device for skin treatment, in the study treatment areas,within the past 6 months (i.e., dermabrasion, laser, RF devices)

• Active smokers (0.5 pack/day) or having quit within 3 months prior to treatment

• Active, chronic, or recurrent infection

• History of compromised immune system or currently being treated with immunosuppressiveagents

• History of sensitivity to analgesic agents, Aquaphor®, topical or local anesthetics (e.g., lidocaine, benzocaine, procaine) or chlorhexidine, povidone-iodine orepinephrine

• Excessive sun exposure and use of tanning beds or tanning creams within 30 days priorto treatment

• Treatment with aspirin or other blood thinning agents within 14 days prior totreatment

• History or presence of any clinically significant bleeding disorder

• Any issue that, at the discretion of the Investigator, would interfere with assessmentof safety or efficacy or compromise the subject's ability to participate in the study

• Treatment with an investigational device or agent within 30 days before treatment orduring the study period