A Trial to Evaluate the Efficacy and Safety of PQ912 in Patients With Early AD

Key Inclusion Criteria:

• Age 50-89 (inclusive) at screening

• Diagnosed as having Mild Cognitive Impairment (MCI) due to Alzheimer's disease (AD)or Mild probable AD according to workgroups of the Diagnostic Guidelines of theNational Institute on Aging and Alzheimer's Association (NIA-AA)

• Mini-Mental State Examination (MMSE) score 20-30 inclusive at screening

• Montreal Cognitive Assessment score (MoCA) < 26 at screening

• Clinical Dementia Rating global score 0.5 or 1 with memory score of > 0.5 atscreening

• Positive CSF AD biomarker signature

• A brain MRI scan within 6 months of screening consistent with a diagnosis ofAlzheimer's disease

• Participants must have a study partner who has frequent interaction with them (approximately >3-4 times per week), will be present for all clinic visits, and canassist in compliance with study procedures.

Key Exclusion Criteria:

• • Significant neurodegenerative diseases and causes of dementia, other than AD,including Parkinson's disease and Huntington's disease, vascular dementia, CJD (Creutzfeldt-Jakob disease), LBD (Lewy Body dementia), PSP (Progressive SupranuclearPalsy), AIDS (Acquired Immunodeficiency Syndrome), or NPH (normal pressurehydrocephalus)

• Meeting Diagnostic Criteria for Possible AD according to workgroups of theDiagnostic Guidelines of the NIA-AA

• Hepatic impairment defined as Child-Pugh class A or more severe liver impairment

• History of moderate or severe skin reactions to medications or current moderate orsevere disease of the skin and subcutaneous tissues

• History of a major depressive episode within the past 6 months of screening

• History of diagnosis of schizophrenia

• History of uncontrolled bipolar disorder within past five years of screening

• History of seizures within past two years of screening

• Contraindication to lumbar puncture and MRI

• Participation in another clinical trial for an investigational agent and havingtaken at least one dose of study drug, unless confirmed as having been on placebo,within 90 days prior to the baseline visit. The end of a previous investigationaltrial is defined as the date of the last dose of an investigational agent.