Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors

Inclusion Criteria:

• Be at least 18 years of age
• Be diagnosed with cancer
• Have stable disease or no evidence of disease
• Report WORST level of fatigue in the past week as moderate to severe (i.e., a score >= 4 on a 0-10 scale, screening measures, question 1)
• Have completed surgery, radiation, and/or systemic intravenous anticancer therapy (e.g., chemotherapy, targeted therapy, immunotherapy) 2 or more months prior toenrollment. Participants currently receiving oral maintenance, targeted, or hormonaltherapy are eligible. Participants receiving intravenous supportive therapy (e.g.,bisphosphonates) are eligible
• Able to read and speak English
• Currently not pregnant or breastfeeding. Women of child-bearing potential must agreeto use adequate contraception, i.e., abstinence, IUD (intrauterine device), hormonalcontraceptive (birth control pills) or barrier method (condoms) prior to study entryand for the duration of study participation
• Be capable of providing written informed consent

Exclusion Criteria:

• Be currently taking any medications that contain bupropion (e.g., Wellbutrin, Forfivo,Aplenzin, or Zyban
• Be taking a monoamine oxidase inhibitor (MAOI), linezolid, or methylene blue within 2weeks prior to enrollment
• Be taking any anti-psychotic medications within a week prior to enrollment
• Have a history of renal impairment (i.e., glomerular filtration rate < 45)
• Have a history of cirrhosis (i.e., Child-Pugh score >= 5)
• Have a history of seizures
• Have a history of bulimia or anorexia nervosa
• Report a history of sensitivity to bupropion
• Report an allergy to lactose
• Have a psychiatric or neurological disorder that would interfere with studyparticipation per physician or physician's designee