Platelet-rich Plasma for Eyebrows

Inclusion Criteria:

1. Males or females 18-85 years old.

2. Subjects are in good health as judged by the investigator.

3. Patients with mild to moderate eyebrow hypotrichosis (modified GEyA grades of 3 and 4 at the time of screening, see Appendix A).

4. Those who have less eyebrows and therefore, desire to enhance eyebrows (modifiedGEyA grades of 3 and 4 at the time of screening, see Appendix A).

5. Subjects who are willing and have the ability to understand and provide informedconsent for participation in the study and are able to communicate with theinvestigator

Exclusion Criteria:

1. Patients with uncontrolled systemic disease (including alopecia areata or any otherform of alopecia) which could inhibit hair growth

2. Patients with thrombocytopenia, platelet dysfunction, hypofibrinogenemia, anemia,cancer, active infections with Pseudomonas, Klebsiella, or Enterococcus, history oftrichotillomania, thyroid diseases, eye diseases, atopic dermatitis, seborrheicdermatitis, lupus erythematosus, scleroderma, leprosy, or syphilis.

3. Patients who have started used agents that may affect eyebrow hair growth (e.g.minoxidil or bimatoprost) within 6 months of screening. Patients who have been usingagents that may affect eyebrow hair growth for at least 12 months may be included ifthe patient agrees to continue their current dosing regimen for the duration of thestudy.

4. Known disease, infection, or abnormality in the treatment area or hair shaft

5. Patients with tattoos, scars, hyperpigmentation, or other features which couldprevent accurate evaluation of hair growth in the eyebrow area.

6. Evidence of another skin condition affecting the treatment area that would interferewith clinical assessments

7. Unwilling to refrain from washing face or using face care products 24 hours beforeand after treatment visits

8. History of a clinically significant hematologic disorder as determined by theinvestigator.

9. Subjects currently receiving anticoagulant or anti-platelet therapy.

10. Subject is known to be HIV positive.

11. Known genetic disorders affecting fibroblasts or collagen, such as achondroplasia,osteogenesis imperfecta, etc.

12. Pregnant or breast feeding

13. Uncooperative patients or patients with neurological disorders who are incapable offollowing directions or who are predictably unwilling to return for follow-upexaminations.

14. Subjects who are unable to understand the protocol or give informed consent (including non-English speaking patients).