Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG)

Last updated: May 22, 2024
Sponsor: Cartesian Therapeutics
Overall Status: Active - Recruiting

Phase

2

Condition

Neuropathy

Sarcopenia

Polymyositis (Inflammatory Muscle Disease)

Treatment

Descartes-08

Clinical Study ID

NCT04146051
MG-001
  • Ages > 18
  • All Genders

Study Summary

This is a Phase IIb study to evaluate the safety and preliminary efficacy of Descartes-08 CAR T-cells in patients with Generalized Myasthenia Gravis

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient must be at least 18 years of age.

  • Patient must have Generalized Myasthenia Gravis at the time of screening.

  • Concomitant immunosuppressive drugs must be deemed necessary by the investigator.

  • Seronegative Patients are included

Exclusion

Exclusion Criteria:

  • Major chronic illness that is not well managed at the time of study entry and in theopinion of the investigator may increase the risk to the patient.

  • Patient is pregnant or lactating.

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: Descartes-08
Phase: 2
Study Start date:
December 04, 2019
Estimated Completion Date:
March 31, 2026

Connect with a study center

  • University of Alberta

    Edmonton, Alberta T6G2C8
    Canada

    Active - Recruiting

  • Barrow Neurological Institute

    Phoenix, Arizona 85013
    United States

    Site Not Available

  • Profound Research

    Carlsbad, California 92011
    United States

    Active - Recruiting

  • The Research Center of Southern California

    Carlsbad, California 92011
    United States

    Active - Recruiting

  • University of California Irvine

    Irvine, California 92697
    United States

    Active - Recruiting

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado 80045
    United States

    Active - Recruiting

  • University of Colorado-Denver

    Aurora, Colorado 80045
    United States

    Site Not Available

  • SFM Clinical Research, LLC

    Boca Raton, Florida 33487
    United States

    Active - Recruiting

  • University of Miami

    Miami, Florida 33136
    United States

    Site Not Available

  • Neurology Associates, P.A.

    Orlando, Florida 32751
    United States

    Active - Recruiting

  • University of South Florida

    Tampa, Florida 33612
    United States

    Active - Recruiting

  • University of Augusta

    Augusta, Georgia 30912
    United States

    Active - Recruiting

  • University of Kansas Medical Center Research Institute

    Kansas City, Kansas 66160
    United States

    Active - Recruiting

  • Dent Neurologic Institute

    Amherst, New York 14226
    United States

    Active - Recruiting

  • University of North Carolina

    Chapel Hill, North Carolina 27599
    United States

    Active - Recruiting

  • Oregon Health & Science University

    Portland, Oregon 97239
    United States

    Active - Recruiting

  • University of Pennsylvania

    Philadelphia, Pennsylvania 19104
    United States

    Active - Recruiting

  • Allegheny Health Network

    Pittsburgh, Pennsylvania 15212
    United States

    Active - Recruiting

  • Vanderbilt University Medical Center

    Nashville, Tennessee 37232-2551
    United States

    Site Not Available

  • Virginia Commonwealth University

    Richmond, Virginia 23219
    United States

    Active - Recruiting

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