Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study

Last updated: January 31, 2025
Sponsor: Wake Forest University Health Sciences
Overall Status: Active - Recruiting

Phase

4

Condition

Hair Loss

Alopecia

Treatment

Doxycyline

Triamcinolone Acetonide

Minoxidil

Clinical Study ID

NCT04207931
IRB00043796
  • Ages 18-60
  • Female

Study Summary

The objective of this study is to examine photos of CCCA patients taken before and after treatment to compare treatment outcomes between different treatment groups

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • African-American women, ages 18-60 years old

  • with a clinical diagnosis and biopsy-proven CCCA, with Central Scalp Alopecia Scaleseverity 1 through 4 will be included in this study

  • These subjects will be seen and treated in Wake Forest Baptist Health DermatologyOutpatient Clinic

Exclusion

Exclusion Criteria:

  • Patients with other forms of hair loss in addition to CCCA will be excluded

  • Other patients to be excluded are those with other forms of inflammatory scalpdisease (with the exception of mild seborrheic dermatitis)

  • patients who have had topical treatment for CCCA within the past 4 months (includingtopical steroids, topical minoxidil, or any other topical hair regrowth medication)

  • patients who have been on a long-term oral antibiotics for hair loss within the pastyear

  • patients who have undergone more than two rounds of intralesional steroid injectionsto the scalp in the past one year.

Study Design

Total Participants: 250
Treatment Group(s): 4
Primary Treatment: Doxycyline
Phase: 4
Study Start date:
April 30, 2018
Estimated Completion Date:
January 31, 2026

Study Description

Treatment groups that patients will be randomized to include 1) topical steroid plus oral antibiotic group, and topical minoxidil after 8 months 2) topical steroid plus intralesional steroid group and topical minoxidil after 8 months. Both these regimens are used as the first-line treatments by clinicians. The objective of this study is to examine photos of CCCA patients taken before and after treatment to compare treatment outcomes between different treatment groups.

In this study, the investigators are looking to determine how standard treatment affects the outcome of central centrifugal cicatricial alopecia; to determine if topical steroid with With Doxycycline has better outcome than topical steroids with intralesional steroids in central centrifugal cicatricial alopecia, and to determine how the addition of topical minoxidil as a treatment changes the outcome of central centrifugal cicatricial alopecia.

Connect with a study center

  • Wake Forest Baptist Health Department of Dermatology

    Winston-Salem, North Carolina 27157
    United States

    Active - Recruiting

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