Cannabidiol and Oral Contraceptive Pills: Exploring a Drug-Drug Interaction

Inclusion Criteria:

• Have regular menses (every 21-35 days)
• Not at risk for pregnancy (not sexually active, using a barrier method of birthcontrol, using a copper IUD for birth control, have a partner with a vasectomy, havehad a tubal ligation, or in a same sex relationship)
• Generally healthy women between the age of 18 to 35 years old
• English speaking

Exclusion Criteria:

• Active users of hormonal contraception

1. For combined methods, if they have recently stopped use, they must have had onenormal menstrual cycle
2. For prior Depo-Medroxyprogesterone Acetate users, they must be off of themedication for 2 months and be having regular menstrual cycles

• Pregnancy (less than 6 weeks prior), breastfeeding (less than 6 weeks prior), a. If participants have a normal menstrual cycle after these events, they may beconsidered for enrollment
• Any absolute/relative contraindications to EE and LNG (MEC category 3 or 4 [12])including impaired liver function, history of deep venous thrombosis, hypertension (> 140/90), diabetes with vascular changes, migraines with aura or neurological changes,history of myocardial infarction, pulmonary embolus, stroke or breast cancer.
• Use of CBD or THC products / Marijuana in the last 30 days
• Use of a known CYP450 inhibitor or inducer (other medication)
• BMI>25
• Metabolic disorders including uncontrolled thyroid dysfunction and Polycystic OvarianSyndrome
• Impaired liver or renal function
• Smoking/vaping/e-cigarettes
• Prior bariatric surgery
• Decisional impairment
• Incarceration