Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD

Last updated: February 14, 2025
Sponsor: Stanford University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Autism

Asperger's Disorder

Williams Syndrome

Treatment

Transcranial magnetic stimulation

Clinical Study ID

NCT04532424
IRB-57738
  • Ages 12-45
  • All Genders

Study Summary

Investigating the efficacy of a form of TMS called theta-burst stimulation for restricted and repetitive behavior in ASD.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Diagnosis of Autism Spectrum Disorder (ASD), Asperger's or Autism.

  2. Meet criteria for ASD on clinical assessments (ADOS-2 or CARS/BOSA if conductedremotely & ADI-R)

  3. Aged between 12-45 years old

  4. Have a reliable informant who can complete relevant questionnaires

  5. Must have previously not responded or not tolerated 2 treatments.

Exclusion

Exclusion Criteria:

  1. Any contraindications for TMS e.g. history of seizures

  2. Pregnancy

  3. Any current or past history of any physical condition which in the investigator'sopinion might put the subject at risk or interfere with study resultsinterpretation.

  4. Active substance use (<1 week) or intoxication verified by toxicology screen--ofcocaine, amphetamines, benzodiazepines

  5. Showing symptoms of withdrawal from alcohol or benzodiazepines

  6. DSM-5 diagnosis of bipolar disorder or a psychotic disorder e.g. schizophrenia.

  7. Significant sensory impairments such as blindness or deafness.

  8. Any other indication the PI feels would comprise data

  9. Current severe insomnia (must sleep a minimum of 4 hours the night beforestimulation)

  10. IQ<50 or not testable using IQ measures and no historical IQ score available

  11. Currently taking Clozapine or another medication that the PI determines increasesthe risk of TMS or may disrupt the efficacy.

  12. A motor threshold that is too high to allow safe/tolerable treatment.

Study Design

Total Participants: 67
Treatment Group(s): 1
Primary Treatment: Transcranial magnetic stimulation
Phase:
Study Start date:
January 04, 2021
Estimated Completion Date:
December 01, 2029

Connect with a study center

  • Stanford University

    Palo Alto, California 94304
    United States

    Site Not Available

  • Robin Libove

    Stanford, California 94305-5719
    United States

    Site Not Available

  • Stanford University

    Stanford, California 94305-5719
    United States

    Active - Recruiting

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