Study of Safety and Tolerability of CFZ533 in Patients With Sjögren's Syndrome

Inclusion Criteria:

1. Participants had to have participated in the TWINSS core study, CCFZ533B2201 (NCT03905525), and had to have completed the entire treatment period up to Week 48and the follow-up period up to Week 60.

2. Signed informed consent had to be obtained prior to participation in the Extensionstudy (i.e., before commencement of the Week 60 assessments of the core study).

3. In the judgment of the Investigator, participants had to be expected to clinicallybenefit from continued iscalimab therapy.

Exclusion Criteria:

1. Sjögren's Syndrome overlap syndromes where another autoimmune rheumatic diseaseconstituted the principle illness, specifically:

• Moderate-to-severe active systemic lupus erythematosus (SLE) with anti-dsDNApositivity and renal involvement, or other organ involvement that impeded onthe ability to score ESSDAI domains

• Active rheumatoid arthritis (RA) that impeded on the ability to score theESSDAI articular domain

• Systemic sclerosis

• Any other concurrent connective tissue disease (e.g., lupus nephritis (LN),large vessel vasculitis (LVV), Sharp syndrome (mixed connective tissue disease)that was active and required immunosuppressive treatment outside the scope ofthis trial and would impede on Sjögren's Syndrome organ domain assessments

2. Use of other investigational drugs other than iscalimab during the core study

3. Active uncontrolled viral, bacterial or other infections requiring systemictreatment at the time of enrollment, or history of recurrent clinically significantinfection or of bacterial infections with encapsulated organisms

4. Pregnant or nursing (lactating) women, where pregnancy was defined as the state of afemale after conception and until the termination of gestation, confirmed by apositive human Chorionic Gonadotropin (hCG) laboratory test

5. Women of child-bearing potential (WOCBP), defined as all women physiologicallycapable of becoming pregnant, unless they were using highly effective methods ofcontraception during dosing and for 14 weeks after stopping the investigationaldrug.

6. Missing ESSDAI (Cohort 1 and Cohort 2) or ESSPRI (Cohort 2) scores in the core studyat Weeks 0 and 4 or Weeks 40 and 48.