The Effect of Dronabinol on Ocular Hemodynamics in Patients With Primary Open Angle Glaucoma

Last updated: May 13, 2025
Sponsor: Medical University of Vienna
Overall Status: Completed

Phase

2

Condition

N/A

Treatment

Placebo

Dronabinol 5 MG

Dronabinol 10 MG

Clinical Study ID

NCT04596826
OPHT-250719
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Glaucoma is among the leading causes for irreversible blindness worldwide. While lowering intraocular pressure (IOP) remains the mainstay of therapy, there are still some patients who progress despite well-controlled IOP. There is evidence from several studies that ocular blood flow and its regulation is impaired in patients with glaucoma. Tetrahydrocannabinol (THC) has been used in the treatment for glaucoma in some countries for several years due to its IOP lowering effect. In addition, there is also evidence that THC features neuroprotective effects and improves ocular hemodynamics. Dronabinol is a synthetic THC that is legally available in several European countries. It has the advantage that exact dosing of THC is possible in contrast to previously applied administration forms such as smoking. Due to its legal status in the past, data about the effect of THC on ocular blood flow and its regulation are sparse. In a recent study conducted in the investigators laboratory they found that single administration of dronabinol leads to a significant increase in optic nerve head (ONH) blood flow without impairing its autoregulatory capacity.The aim of the present study therefore is to investigate whether single administration of dronabinol alters optic nerve head (ONH) blood flow in patients with open angle glaucoma. In addition, other parameters for ocular blood flow will be measured, in particular retinal blood flow, retinal oxygen saturation and retinal neurovascular coupling. The study will be conducted in a parallel-group, randomized, double-masked, placebo-controlled, cross-over design. Patients will be randomized to either receive 5mg or 10mg dronabinol on one study day. Other studies investigating retinal hemodynamics or IOP after administration of THC also have used similar or slightly higher doses.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of manifest open angle glaucoma as defined as pathological optic discappearance, glaucoma hemifield test outside normal limits and/or untreated IOP ≥ 21mmHg on at least three measurements in the medical history.

  • Mean deviation in the visual field test < 10dB

  • Informed consent signed and dated

  • Patient aged ≥ 18 years old

  • Ametropia ≤ 6 diopters

  • Normal findings in the medical history and physical examination including ECGunless the investigator considers an abnormality to be clinically irrelevant

  • Normal findings in the laboratory testing unless the investigator considers anabnormality to be clinically irrelevant

  • Nonsmokers

Exclusion

Exclusion Criteria:

  • Exfoliation glaucoma

  • Pigmentary glaucoma

  • Secondary glaucoma

  • History of acute angle closure

  • Intraocular surgery within the last 6 months

  • Filtration surgery for glaucoma at any time

  • Laser procedure for glaucoma within the last 12 months Visual field notperformed or not available within 6 months

  • Ocular inflammation or infection within the last 3 months

  • Regular use of medication that potentially could interact with THC, abuse ofalcoholic beverages or drugs

  • History of drug or alcohol abuse

  • Psychiatric disorders in the medical history

  • Risk for drug dependence as evaluated by a psychiatrist

  • Participation in a clinical trial in the 3 weeks preceding the study

  • Positive urine drug test at the screening examination or on the study days

  • Positive alcohol breath test at the screening examination or on the study days

  • Regular consumption of cannabis and inability to not consume cannabis duringthe study period

  • Symptoms of a clinically relevant illness in the 3 weeks before the first studyday

  • History or presence of gastrointestinal, liver or kidney disease, or otherconditions known to interfere with distribution, metabolism or excretion ofstudy drugs

  • Blood donation during the previous 3 weeks

  • Known hypersensitivity to any of the components of the IMP under investigationor other study medication

  • History or family history of epilepsy

  • Pregnant or breast-feeding women

  • Women of childbearing potential (neither menopausal, nor hysterectomized, norsterilized) not using effective contraception (oral contraceptives,intra-uterine device, contraceptive implant or condoms)

Study Design

Total Participants: 51
Treatment Group(s): 3
Primary Treatment: Placebo
Phase: 2
Study Start date:
November 11, 2020
Estimated Completion Date:
October 02, 2024

Connect with a study center

  • Department of Clinical Pharmacology, Medical University Vienna

    Vienna, 1090
    Austria

    Site Not Available

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