Per-Operative Radiotherapy by Papillon +TM in Localized Breast Cancer

Inclusion Criteria:

• Patient with invasive ductal adenocarcinoma <=2cm, evaluate on all radiologicalexams;

• Women aged 65 years or older (patients 65 years of age in the year may be included);

• Grade 1 or 2 unifocal adenocarcinoma, all index KI67, positive HR, negative HER2status;

• T0 or T1, N0 radio-clinic;

• Operable patient with breast volume compatible with conservative surgery;

• Patient with prior malignancy or other concurrent malignancies are eligible,including bilateral breast cancer

• Patients who have been made aware of the information sheet and have given theirwritten signed informed consent;

• Patients benefitting from social health insurance coverage

Exclusion Criteria:

• Age less than 65 years (except if 65 years obtained during the year)

• Patient with an exclusive in situ carcinoma

• Patient with lymphatic invasion / peri-nerve involvement / vascular emboli

• Patient with a lobular adenocarcinoma

• Patient with metastatic disease

• Multifocal tumor

• Patient with grade 3 or N+ disease

• N1 proved by ultrasound guided

• patient unable to express her consent

• Patient deprived placed under the authority of a tutor

• Female patients who are pregnant or breastfeeding

• Vulnerable patient: as defined in article L1121-5 à -8