Effect Alveolar Recruitment Manoeuver on Stroke Volume a Randomized Study

Last updated: March 15, 2021
Sponsor: University Hospital, Caen
Overall Status: Active - Recruiting

Phase

N/A

Condition

Anesthesia

Treatment

N/A

Clinical Study ID

NCT04802421
CHU Caen Normandie 19-024
  • Ages > 18
  • All Genders

Study Summary

Objective: to compare the effect of alveolar recruitment manouver through stepwise increase and decrease in airway pressure or sustained 30 secondes 30 cmH2O continuous positive airway pressure on cardiac stroke volume estimated by oesophageal doppler in preload independent anesthetized patients scheduled for surgery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • adult patients scheduled for major surgery requiring hemodynamic monitoring
  • written signed informed consent

Exclusion

Exclusion Criteria:

  • pregnancy
  • non sinusal heart rate
  • known cardiac right ventricular failure or arterial pulmonary hypertension
  • pneumothorax
  • known pulmonary emphysema

Study Design

Total Participants: 70
Study Start date:
March 12, 2021
Estimated Completion Date:
April 01, 2022

Study Description

Following anesthesia and preload optimisation guided by cardiac stroke volume, patients will be randomised to one alveolr recruitment manoeuver :

  • stepwise increase and decrease in positive airway pressure

  • sustained 30 secondes 30 cmH2O continuous positive airway pressure The primary objective is the change in cardiac stroke volume.

Connect with a study center

  • CHU de Caen

    Caen, 14000
    France

    Active - Recruiting

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