Persona Revision Knee System Outcomes

Inclusion Criteria:

1. Male or female of at least 18 years of age at the time of screening.

2. Signed an institutional review board approved informed consent.

3. Willingness and ability to comply with the study procedures and visit schedules andability to understand and follow oral and written post-operative care instructions.

4. Previous medical diagnosis/ history of at least one of the following conditionsrequiring treatment using the Persona Revision Knee System within a pre-specifiedstudy variant configuration (cohort), in accordance with the instructions for use (IFU):

5. Rheumatoid arthritis, osteoarthritis, traumatic arthritis or polyarthritis

6. Collagen disorders, and/or avascular necrosis of the femoral condyle

7. Post-traumatic loss of joint configuration, particularly when there ispatellofemoral erosion, dysfunction or prior patellectomy

8. Moderate valgus, varus, or flexion deformities

9. The salvage of previously failed surgical attempts or for a knee in whichsatisfactory stability in flexion cannot be obtained at the time of surgery

10. A pre-operative Knee Society Knee Score (objective assessment) ≤ 80.

Exclusion Criteria:

1. Presence of clinically observed active or suspected latent infection in the affectedjoint at the time of procedure.

2. Presence of of local/systemic/distant focal infection that may affect orhematogenously spread to the prosthetic joint.

3. Skeletal immaturity or insufficient bone stock on femoral or tibial surfaces whichcannot provide adequate support and/or fixation to the prosthesis.

4. Diagnosed with neuropathic arthropathy, osteoporosis, or any loss of musculature orneuromuscular disease that compromises the affected limb.

5. Presence of a stable, painless arthrodesis in a satisfactory functional position inthe affected joint.

6. Severe instability of the affected joint secondary to the absence of collateralligament integrity.

7. Diagnosis of rheumatoid arthritis in conjunction with any of the following at thetime of screening:

1. An ulcer of the skin

2. History of recurrent breakdown of the skin

3. Use of steroids

9. Patient requires simultaneous bilateral knee surgery for treatment of diagnosedcondition.

10. Pregnant or women planning to become pregnant during the time they will beparticipating in the study.

11. Any documented clinically significant degree of cognitive impairment or othercondition, finding, or psychiatric illness at screening which, in the opinionof the Investigator, could compromise patient safety or interfere with theassessment of the safety and treatment effects of the study procedure.

12. Any patient who is institutionalized, or with a known drug or alcoholdependence currently or within the last year.