Eccentric Manual Resistance Training in Patients With Ischemic CMP

Phase

N/A

Condition

Coronary Artery Disease

Congestive Heart Failure

Cardiomyopathy

Treatment

Eccentric manual resistance training

Concentric manual resistance resistance training

Clinical Study ID

NCT04829955

Cardio eccentric protocol 3.5

Ages 45-85
All Genders

Study Summary

Patients with ischemic cardiomyopathy and mildly reduced ejection fraction suffer from reduced functional capacity and fatigue caused by loss of muscle strength and reduced aerobic capacity.

A few studies have shown that structured endurance and resistance training programs were able to improve walking capacity and limb strength.

Although both concentric and eccentric training programs are beneficial for these patients, eccentric training is less stressful to the cardiovascular system.

The aim of the study is to determine if eccentric-orientated body weight and manual resistance training in ischemic cardiomyopathy patients will lead to superior results compared to concentric training.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Male / female, 45-85a
Ischemic cardiomyopathy with mildly reduced ejection fraction (40 -50%)
Coronary heart disease

Exclusion

Exclusion Criteria:

Acute coronary syndrome, myocarditis or pericarditis in the last 3 months
Cardiac decompensation in the last 3 months
Severe symptomatic heart failure NYHA IV (New York Heart Association)
Device - carrier (ICD= Intracardial Defibrillator, CRT= Cardiac ResynchronizationTherapy, PM=Pacemaker)
Hemodynamically significant valvular disease
Symptomatic cardiac arrhythmia
Intractable, uncontrolled hypertension (repetitive blood pressure > 150/100)
Severe comorbidities, which lead to study exclusion by the investigator
Pregnancy / nursing

Study Design

Eccentric manual resistance training

June 29, 2022

December 12, 2023

Study Description

BACKGROUND: Eccentric resistance training demonstrated positive effects in ischemic cardiomyopathy patients in several studies. These studies were mainly set on device-based training interventions comparing eccentric-orientated and concentric-orientated training. Eccentric-orientated training induced comparable positive effects on cardiac and functional levels and even better effects on muscle strength improvement.

RESEARCH AIMS: The aim of the study is to determine if eccentric-orientated body weight and manual resistance training in ischemic cardiomyopathy patients will allow a more significant improvement in maximum voluntary contraction force of the knee extensors compared to concentric training.

In contrast to previous studies, these interventions will be set without use of training devices.

In addition, changes in the muscle cross section of the quadriceps muscle will be calculated by skeletal muscle ultrasound. Functional changes and quality of life will be assessed using one minute sit to stand test, six minutes walking test and Kansas City Cardiomyopathy Questionnaire. Cardiac outcome parameters will be assessed by using body composition and hemodynamic parameters as well as echocardiography, laboratory values and specific biomarkers for sarcopenia / cachexia.

METHODS: The investigators propose to run a monocentric, prospective, double arm, open, randomized controlled trial. Eccentric-orientated training will be delivered to 30 ischemic cardiomyopathy patients.

These patients will be randomized into two groups at the beginning, followed by a 6-weeks observation phase (without intervention for internal quality control of the measurement parameters). The intervention-phase will consist of six weeks of three times weekly either eccentric or concentric-oriented training.

Outcome measurements will take place after randomization, after 6 weeks of observation as well as after the intervention phase

Connect with a study center

Klinik Ottakring
Vienna, 1160
Austria
Site Not Available

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