The Use of Amantadine in the Prevention of Progression and Treatment of COVID-19 Symptoms

Inclusion Criteria:

• Men and women aged 18 and over
• Can give informed consent
• Confirmed positive result for SARS-CoV-2 within 72 hours from the date the result wasissued (according to the laboratory report)
• Patient presently symptomatic with one or more of the following symptoms: fever,cough, myalgia, mild dyspnoea, chest pain, diarrhea, nausea, vomiting, anosmia, lackof taste, sore throat, nasal congestion
• At initial screening, the subject will report at least one and no more than 3 of thefollowing risk factors for clinical worsening: age ≥40, obesity, hypertension,diabetes, pulmonary disease (e.g., asthma, COPD), and immune disorders (e.g.rheumatoid arthritis, lupus), neurological diseases: e.g. after a distant stroke ortrauma to the brain, multiple sclerosis, dementia and other neurodegenerativediseases)
• Patients hospitalized due to meeting the above criteria and requiring observation in ahospital or outpatient setting.

Exclusion Criteria:

• Disease severe enough to meet the study's primary endpoint of clinical worsening (eg,current O2 saturation <92% with patient exposure to room air, current use ofsupplemental oxygen to maintain O2 saturation ≥ 92%).
• WHO score ≥4 (requires oxygen therapy during hospitalization)
• Concomitant diseases which, in the opinion of the attending physician, prevent thepatient from participating in the study, such as: decompensated cirrhosis, activeulcer disease, epilepsy and symptomatic convulsions, untreated angle-closure glaucomadetermined on the basis of the patient's interview and / or medical documentation . Inaddition, immunocompromised patients (solid organ transplant, BMT, AIDS, renal failure (patients with renal impairment may develop drug poisoning) or other diseases notmentioned and other diseases treated with biological, immunological and / or steroidsin high doses will not be eligible for the study. doses (> 20 mg prednisone daily).
• Hypersensitivity to any component of the preparation, severe congestive heart failure,cardiomyopathy, myocarditis, II-III degree AV block, bradycardia, clinicallysignificant prolongation of the QT interval, or a family history of congenital long QTsyndrome, severe ventricular arrhythmias (including torsade de pointes), concomitantuse of drugs that prolong the QT interval, hypokalaemia, hypomagnesaemia,
• Pregnancy, the period of breastfeeding.
• Parallel intake of memantine or other drugs acting on the CNS (neuroleptics,anxiolytics, antiepileptic drugs, antidepressants).
• Other neurological conditions with agitation or confusion, delirium syndromes orpsychoses.
• Receipt of a partial or full vaccination schedule against SARS-CoV-2 is also anexclusion criterion from the study.