A Study of Surgical Interventions in Fistulizing Conditions

Inclusion Criteria:

Participants with CPF-CD

1. CPF-CD that meets one or more of the following criteria:

• High inter-sphincteric, high trans-sphincteric, extra-sphincteric orsupra-sphincteric fistula, or

• Presence of greater than or equal to (>=) 2 external openings, or

• Associated perianal abscess(es)

2. Physician has made the decision to treat with a specific surgical intervention.Procedures may include:

• Fistulotomy, fistula plug, fibrin glue, advancement flap (AF), ligation ofinter-sphincteric fistula tract (LIFT), flap repair, fistulectomy, proctectomy,stem cell therapy, other; and seton for palliative purposes.

Participants with CD-RVF: Rectovaginal fistula per physician diagnosis

1. Physician has made the decision to treat with a specific surgical intervention.Procedures may include:

• Fistulotomy, fistula plug, fibrin glue, AF, LIFT, flap repair, fistulectomy,proctectomy, stem cell therapy, gracilis muscle interposition/tissue grafts, martiusprocedure, abdominal procedures, other; and seton use for palliative purposes.

Participants with CCF:

1. Complex cryptoglandular fistula that meets one or more of the following criteria:

• Mid or high trans-sphincteric, or

• Anterior in women, or

• Horseshoe fistula

2. Physician has made the decision to treat with a specific surgical intervention.Procedures may include:

• Fistulotomy, fistula plug, fibrin glue, AF, LIFT, flap repair, fistulectomy,proctectomy, stem cell therapy, other; and seton use for palliative purposes

Exclusion Criteria:

Participants who meet any below mentioned criterion among CPF-CD, CD-RVF, and CCF diagnosis will be excluded from the study.

1. Current participation in interventional clinical trials.

2. Has CPF-CD: fistula connection to bladder or another organ

3. Has CCF: diagnosis of Inflammatory Bowel Disease (IBD), including UlcerativeColitis, and Crohn's Disease (CD).