Restricted or Liberal Antibiotics After Appendectomy - Denver Health

Inclusion Criteria:

• Age ≥ 18 years

• Planned appendectomy (laparoscopic or open) for simple or complicated (perforated organgrenous) appendicitis

• Working telephone number or reliable method to contact patient after hospitaldischarge

Exclusion Criteria:

• Unable to consent

• Pregnant Women

• Prisoners

• Immunocompromised as determined by clinical team, or patients actively receivingsteroids, chemotherapy, or immunosuppressing medications (for example tacrolimus),or patients with active hematologic malignancy affecting the immune system,leukopenia, or end-stage AIDS

• Heart failure

• Allergy to bupivacaine

• Unlikely to comply with treatment or follow-up

• Inpatient consultation for appendicitis

• Clinically suspected of sepsis based on Sepsis-3 definition

• Current use of antibiotics for other indications

• Uncontrolled hyperglycemia or Type 1 Diabetes

• Surgeon preference

• Patient preference

• Research team unavailable