Study on the Efficacy of Vetiver Essential Oil Aroma on Depression/Anxiety People

Last updated: June 20, 2022
Sponsor: Chung Shan Medical University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Anxiety Disorders

Depression

Panic Disorders

Treatment

N/A

Clinical Study ID

NCT05024136
CS1-20030
  • Ages 20-65
  • All Genders

Study Summary

In this study, subjects with depression/anxiety inhaled the essential oil, which contained sedative, soothing, and relaxing active ingredients to stimulate the olfactory nerve. The essential oil further transmitted to the limbic system that controls emotions in the brain, and then affected the human's mood. The natural aroma can not only awaken the limbic system's memory of aroma but also reflect the subconscious area of the brain, with physiological changes (such as controlling blood pressure, breathing, heartbeat, stress changes, memory, and hormonal coordination.) This study monitors the subject's autonomic nerve parameters before and after aromatherapy to obtain the olfactory cerebral nervous system to convey the message. When the study finishes, we expected to help the subject to relax and soothe the mind.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Depressed/anxious people (diagnosed as a single episode of major depression,recurrence of major depression, mild depression, panic disorder, and anxiety.) Thosediagnosed with symptoms of depression, and anxiety related to stress adjustmentdisorder, and willing to cooperate with the study.
  2. Age 20-65 years old

Exclusion

Exclusion Criteria:

  1. an alcoholic
  2. Uncontrolled diabetes
  3. Those who have had a stroke in the last year
  4. Pregnant and lactating women
  5. People with liver or heart disease
  6. Arrhythmia or those with a heart rhythm regulator
  7. Those whose heart has already been fitted with a cardiac catheter stent
  8. Those who have used central nervous system stimulants (regardless of the length oftime)
  9. Those who are allergic to essential oils
  10. Those who have used aromatherapy within a month
  11. Subjects request to withdraw from the trial
  12. The host feels unsuitable to continue the study

Study Design

Total Participants: 60
Study Start date:
January 20, 2021
Estimated Completion Date:
March 31, 2023

Study Description

Subjects receive three times 30 mins aromatherapy of Limon or Vetiver essential oil per time for the month. Anthropometric measurements such as blood pressure (systolic blood pressure [SBP] and diastolic blood pressure [DBP]), autonomic nerve parameters including a. SDNN (standard deviation of all normal to normal intervals index); b. HRV（heart rate variability）; c. LF（0.04-0.15 Hz）and HF（0.15-0.4 Hz）were measured every week. PSQI（Pittsburgh sleep quality index）and HADS (Hospital Anxiety and Depression Scale) were measured initial and ten ends.

Connect with a study center

  • Chung Shan Medical University

    Taichung,
    Taiwan

    Active - Recruiting

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