A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants

Inclusion Criteria:

• Participants who are age 12 to <18 years at the time of randomization

• Participants who are age 5 to <12 years (younger participant cohort) at the time ofrandomization once recruitment is open. (Investigators will be notified by theSponsor when recruitment is open to this younger population)

• International Society of Nephrology and the Renal Pathology Society (ISN/RPS) 2003Class III or IV active LN demonstrated on renal biopsy performed in the 12 monthsprior to or during screening

• Class V disease may be present in addition to Class III or IV LN, but participantswith isolated Class V disease are not eligible

• Diagnosis of SLE according to the Systemic Lupus International Collaborating Clinics (SLICC) 2012 criteria

• Significant proteinuria defined by a UPCR above > 0.5 based on a first-morning void (FMV) collection at screening

• During the 12 months prior to or during screening, all participants must havereceived at least one dose of pulse-range IV methylprednisolone (typically 30 mg/kg,maximum of 1000 mg per dose) or equivalent for the treatment of the current episodeof active LN.

Exclusion Criteria:

• Severe, active central nervous system (CNS) SLE, including retinitis, poorlycontrolled seizure disorder, acute confusional state, myelitis, stroke, cerebellarataxia, or dementia

• Sclerosis in >50% of glomeruli on renal biopsy

• Purely chronic Class III(c) or Class IV(c) disease on renal biopsy, defined as theabsence of any active lesions

• Presence of rapidly progressive glomerulonephritis

• Pure Class V LN

• Intolerance or contraindication to study therapies

• Active infection of any kind (excluding fungal infection of nail beds) or any majorepisode of infection requiring hospitalization or treatment with IV anti-infectivemedications within 4 weeks prior to screening, or completion of oral anti-infectiveswithin 2 weeks prior to randomization

• History of or currently active primary or secondary immunodeficiency, includingknown history of HIV infection and other severe Immunodeficiency blood disorders

• History of serious recurrent or chronic infection

• History of or current cancer, including solid tumors, hematological malignancies,and carcinoma in situ (except basal cell carcinoma and squamous cell carcinoma ofthe skin that have been excised and cured) within the past 5 years

• Significant or uncontrolled concomitant medical disease which, in the investigator'sopinion, would preclude participant participation

• Currently active alcohol or drug abuse or history of alcohol or drug abuse