Rescues On Reperfusion Damage In Cerebral Infarction by Nelonemdaz

Inclusion Criteria: The trial subjects should satisfy all the following criteria.

1. Adults≥19 years
2. Patients who can start endovascular therapy within 12 hours after the symptomaticonset of Ischemic stroke.
3. NIHSS on screening time point ≥ 8 points
4. Patients whose general condition was favorable enough to perform daily activitieswithout the help of others one day prior to the ischemic stroke onset (a person withmRS 0 or 1)
5. Patients whose CTA or MRA confirmed internal carotid artery occlusion and M1 or M2occlusion of the middle cerebral artery, that are the types of major cerebral arteryocclusion that can cause acute cerebral infarction and are subject to endovasculartherapy.
6. Patients with early ASPECTS point≥4 (Noncontrast brain cross-section CT or Braincross-section MRI diffusion weighted imaging)
7. Patients who spontaneously submitted a written informed consent to participation onthis clinical study.

Exclusion Criteria: A patient who meets any one of the conditions below cannot participate in the Clinicaltrial.

1. Patients who meet the following exclusion criteria on imaging of endovascular therapy ① Patients whose occlusion location that can cause an acute ischemic stroke in the CTA (CT angiography) image meets under the following conditions: A. Occlusion of bilaterallarge artery B. Simultaneous infiltration of anterior and posterior circulation
2. Patients who have contraindication to contrast media for brain imaging.
3. Patients who are receiving renal replacement therapy such as dialysis due to acute orterminal nephropathy at screening point.
4. Patients who were diagnosed with cancer or received cancer therapy within 6 months atscreening or have recurrent or transitional cancer.
5. Patients have high body temperature of 38oC or more and need antibiotic therapy due tomedical opinion of infectious disease at screening.
6. Patients who are having pharmacotherapy due to liver diseases such as hepaticcirrhosis, etc. at screening point.
7. Patients who are pregnant or lactating. However, only a woman who has no possibilityof pregnancy can participate in this clinical research. Woman with child-bearing potential can be defined as the woman who has not had theclear menopause or who has not had surgical treatment that makes pregnancy impossible.
8. Patients who have participated in other clinical trial within past 6 months at thescreening time as a base. However, in case of participation of observatory experiment,the patient can participate in this clinical trial.
9. Patients who are determined unsuitable for participation in this clinical trial due toother reasons