A Study to Assess the Efficacy and Safety of HMI-115 in Subjects with Endometriosis-Associated Pain

Inclusion Criteria:

1. Pre-menopausal female subjects, between 18 and 49 years of age, inclusive, at thetime of signing informed consent.

2. Subject must have a clinical diagnosis of endometriosis (laparoscopy or laparotomy)as documented by medical records within 10 years before screening.

3. Subject must have a Composite Pelvic Signs and Symptoms Score total score of ≥ 6with a score of at least 2 for DYS and at least 2 for NMPP at screening.

4. Subject agrees not to participate in another interventional study whileparticipating in the present study.

Exclusion Criteria:

1. Subject is pregnant or breastfeeding or is planning a pregnancy during the studyperiod.

2. Subject has chronic pelvic pain that is not caused by endometriosis or has any otherchronic pain syndrome or other chronic therapy, or that would interfere with theassessment of endometriosis-related pain

3. Subject has clinically significant gynecologic condition other than endometriosis

4. Subject has previous history of a severe, life-threatening or other significantsensitivity to any opioids or non-steroidal anti inflammatory drugs (NSAIDS) or anycontraindication to their use such as gastrointestinal ulcer or bleeding

5. Subject has history of hysterectomy and/or bilateral oophorectomy

6. Subjects with past or present pituitary tumor growth

7. Subjects has a history of osteoporosis or other metabolic bone disease