Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects

Inclusion Criteria:

1. Subject has at least a 6 month history of migraine (with or without aura) andincluding the following:

2. 14 or less headache days per month during the 3 month period prior to theScreening Visit

3. 6 or more migraine days during the Observation Period

4. 14 or less headache days during the Observation Period

5. Pediatric Migraine Disability Assessment Scale (PedMIDAS) Disability Score of >10 to ≤50, indicating mild (score of 11 to 30) or moderate (score of 31 to 50)disruption in daily activities, as assessed at the Baseline (Randomization)Visit

6. Ability to verbally distinguish migraine attacks from tension/cluster or othertypes of headaches

7. Migraine attacks, on average, lasting 4 - 72 hours if untreated

8. Subjects on prophylactic migraine medication are permitted to remain on therapyif the dose has been stable for at least 3 months (12 weeks) prior to theScreening Phase, and the dose is not expected to change during the course ofthe study. 2) Male and female subjects ≥ 6 to <18 years; subjects must be lessthan 18 at the time of signing assent / consent. 3)Subjects must have a weight of ≥40 kg (child cohort requirement ≥15 kg) atthe Screening Visit.

Exclusion Criteria:

1. Subjects with a history of basilar migraine, cluster headaches, or hemiplegicmigraine

2. The subject has a continuous migraine (defined as an unrelenting headache) within 1month prior to Screening Visit.

3. The subject has a history or diagnosis of complications of migraine

4. The subject has a confounding and clinically significant pain syndrome that mayinterfere with the subject's ability to participate in this study.

5. The subject has any current psychiatric condition that is uncontrolled and/oruntreated for a minimum of 6 months prior to the Screening Visit. Subjects with alifetime history of psychosis and/or mania are excluded.

6. History of suicidal behavior or the subject is at risk of self-harm or harm toothers.

7. History of major psychiatric disorder.

8. The subject has a current diagnosis or history of substance abuse

9. The subject has a history of moderate or severe head trauma or other neurologicaldisorder (including seizure disorder) or systemic medical disease that is, in theinvestigator's opinion, likely to affect central nervous system functioning.