A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

Inclusion Criteria:

• Parts A and B:

• Participants must have one of the following histologically- orcytologically-confirmed metastatic or unresectable solid tumor types

• Non-small cell lung cancer (NSCLC)

• Head and neck squamous cell carcinoma (HNSCC) (except nasopharyngealcancer)

• Esophageal squamous cell carcinoma (SCC)

• Triple negative breast cancer (TNBC)

• Participants must have disease that is relapsed or refractory, that hasprogressed on approved therapies, be intolerant to or refused such therapies,or such and therapies are contraindicated and in the judgement of theinvestigator, should have no appropriate SoC therapeutic option

• Participants must have PD-L1 expression based on historical testing

• Part C:

• Participants must have disease that is relapsed or refractory or be intolerantto SoC therapies and must have one of the following tumor types

• HNSCC

• Participants with HNSCC must have histologically orcytologically-confirmed HNSCC

• NSCLC

• Participants must have histologically or cytologically-confirmedNSCLC. Participants with SCC and non--SCC histology are eligible.Note: Participants with a neuroendocrine component or histology arenot eligible.

• Esophageal SCC

• Ovarian cancer

• Melanoma

• TNBC

• Gastric cancer

• Participants must have been previously tested for PD-L1 expression and shouldhave PD-L1 expression ≥1 or <1 by CPS or TPS based on historical testing

• Part D and Part E:

• Participants must have histologically or cytologically-confirmed disease of theHNSCC or NSCLC

• Participants must have PD-L1 expression based on historical testing

• Participants with NSCLC; PD-L1 expression ≥ 1% by TPS

• Participants with HNSCC; PD--L1 expression ≥1 by CPS

• Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1

• Measurable disease per RECIST v1.1 at baseline

Exclusion Criteria:

• History of another malignancy within 3 years of first dose of study treatment or anyevidence of residual disease from a previously diagnosed malignancy.

• Known active central nervous system metastases. Participants with previously-treatedbrain metastases may participate provided they:

• Are clinically stable for at least 4 weeks prior to study entry after brainmetastasis treatment

• Have no new or enlarging brain metastases

• And are off of corticosteroids prescribed for symptoms associate with brainmetastases for at least 7 days prior to first dose of study treatment

• Lepto-meningeal disease

• Prior treatment with an anti-PD-L1 agent within less than 5 half-lives. Thisduration of time will vary according to the half-life of the specific agent.

• Previous receipt of an monomethylauristatin E (MMAE)-containing agent.

• Pre-existing neuropathy ≥Grade 2 per National Cancer Institute Common TerminologyCriteria for Adverse Events (NCI CTCAE) v5.0.

There are additional inclusion criteria. The study center will determine if criteria for participations are met.