Efficacy and Safety Study of Rimegepant in Episodic Migraine Prevention With Multiple Dosing Regimens

Inclusion Criteria:

1. Target Population: Subject has at least 1 year history of episodic migraine (with orwithout aura) consistent with a diagnosis according to the InternationalClassification of Headache Disorders, 3rd Edition, including the following:

1. Age of onset of migraines prior to 50 years of age

2. Migraine attacks, on average, lasting 4-72 hours if untreated

3. Per subject report, 4-14 migraine attacks per month within the last 3 months priorto the Screening Visit (month is defined as 4 weeks for the purpose of this protocol

Exclusion Criteria:

1. Sex and Reproductive Status:

2. WOCBP who are unwilling or unable to use an acceptable contraceptive method orabstinence to avoid pregnancy for the entire study and for 60 days after thelast dose of study drug

3. Women who are pregnant or breastfeeding

4. Women with a positive pregnancy test at screening or prior to study drugadministration

5. Prohibited Medications:

6. Use of prophylactic migraine medication within 30 days prior to the ScreeningVisit.

7. History of use of analgesics (e.g., non-steroidal anti-inflammatory drugs [NSAIDs] or acetaminophen) on ≥ 15 days per month during the 3 months (12weeks) prior to the Screening Visit.

8. Use of medication accepted for treatment of acute migraine for a nonmigraineindication on ≥ 15 days per month during the 3 months (12 weeks) prior to theScreening Visit.

9. Subjects who previously discontinued biologic migraine medication must havedone so at least 6 months (24 weeks) prior to the Screening Visit.

10. Subjects taking a prohibited medication as defined per protocol