ADH1 and ADH2 Disease Monitoring Study (DMS)

Key Inclusion Criteria:

• Have a documented activating variant or variant of uncertain significance of theCASR gene causative of ADH1 or documented activating variant or variant of uncertainsignificance of the GNA11 gene causative of ADH2 associated with a clinical syndromeof hypoparathyroidism prior to enrollment

Note: Acceptable documentation includes CASR or GNA11 genetic analysis report. If no prior documented CASR or GNA11 gene variant or variant of uncertain significance, potential participants can undergo CASR and GNA11 gene variant analysis at Screening.

• Be willing and able to provide informed consent or assent after the nature of thestudy and its details have been explained, and prior to any research-relatedprocedures

• Be willing and able to provide access to prior medical records including imaging,biochemical, and diagnostic and medical history data, if available

• Be willing and able to comply with the study visit schedule and study procedures

Key Exclusion Criteria:

• Have serious medical or psychiatric comorbidity that, in the opinion of theInvestigator, would present a concern for participant safety or compromise theability to provide consent or assent, or comply with the study visit schedule andstudy procedures

• Enrollment in an interventional clinical study at the time of DMS Screening visit

Note: Other protocol defined Inclusion/Exclusion criteria may apply.