GAMBIT Task with PTSD and Healthy Control Participants

Inclusion Criteria:

• Male or female aged 18-55 years

• Participants must be able to provide informed consent

• Participants must have a level of understanding of the English language sufficientto agree to all tests and examinations required by the study and must be able toparticipate fully in the informed consent process

• Must meet criteria for one of the following study groups:

• PTSD Group: i. Meets diagnostic criteria for current PTSD according to the Diagnostic andStatistical Manual of Mental Disorders-Fifth Edition (DSM-5)

1. Has been exposed to a Criterion A trauma of the civilian type (e.g.,non-combat, threatened or actual interpersonal violence) or non-civilian
2. Must have a total score ≥ 25 on the CAPS-5 (past-month version) at thetime of screening, indicating moderate PTSD symptom severity.

• Healthy Control Group: i. Has no lifetime history of any psychiatric disorder

Exclusion Criteria:

• Current or lifetime history of schizophrenia or other psychotic disorder, bipolardisorder, obsessive-compulsive disorder (OCD), eating or feeding disorder,neurodevelopmental disorder, or neurocognitive disorder;

• Any neuropsychiatric disorder that is judged to be the primary presenting problem,other than that which is specified as study group eligibility criteria;

• Substance use disorder within the past 1 year;

• Urine toxicology positive for illicit drugs or dis-allowed concomitant medicationsas per study protocol; intermittent cannabis use that does not meet criteria for asubstance use disorder may be permitted under the protocol.

• Suicidal ideation or risk of self-harm that is judged by the PI to be clinicallysignificant and to warrant intervention

• Concurrent treatment with opioid medication, or with long-acting or daytimeshort-acting benzodiazepines within two weeks of study start

• Current cognitive impairment, as defined by a score <23 on the Montreal CognitiveAssessment (MoCA)

• Estimated IQ <80

• Currently receiving evidence-based psychotherapy for PTSD (e.g., prolonged exposure,cognitive processing therapy).