Reactogenicity, Immunogenicity and Inflammatory Response by New COVID-19 Vaccine Platforms

Last updated: April 6, 2022
Sponsor: Korea University Guro Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Inflammation

Covid-19

Treatment

N/A

Clinical Study ID

NCT05315856
2021GR0099
  • Ages 19-59
  • All Genders

Study Summary

Analysis of humoral antibody and cytokine kinetics after vaccination with either BNT162b2 or ChAdOx1 nCoV-19 vaccine and factors influencing the vaccine immunogenicity

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Volunteers who provide the informed consent after either BNT162b2 or ChAdOx1vaccination
  • healthy adults without underlying medical condition

Exclusion

Exclusion Criteria:

  • Volunteers who had ever infected with SARS-CoV2 were excluded.

Study Design

Total Participants: 120
Study Start date:
March 01, 2021
Estimated Completion Date:
December 31, 2022

Study Description

There is a different aspect of reactogenicity between BNT162b2 and ChAdOx1 nCoV-19 vaccine. Both new platform vaccines were concerned if they would elicit more significant local or systemic reactogenicity compared to the conventional vaccines. Previous studies had reported that immune cells such as mast cells and macrophages are activated just after vaccination, and release proinflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α. The post-vaccination kinetics of inflammatory cytokines would be variable by each vaccine platform, and might be associated with reactogenicity. It is an interesting issue to be investigated whether the reactogenicity following newly developed BNT162b2 and ChAdOx1 would be associated with immunogenicity and inflammatory response or not. To better clarify these uncertainties, we evaluated the change of antibody response between BNT162b2 and ChAdOx1 over three months post-vaccination, in relation to the kinetics of inflammatory cytokines and reactogenicity.

Connect with a study center

  • Ajou University School of Medicine

    Suwon, Gyeonggi-do
    Korea, Republic of

    Active - Recruiting

  • Kangnam Sacred Heart Hospital

    Seoul,
    Korea, Republic of

    Active - Recruiting

  • Korea University Guro Hospital

    Seoul,
    Korea, Republic of

    Active - Recruiting

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