A Study of JNJ-55308942 in the Treatment of Bipolar Depression

Inclusion Criteria:

• Have a primary diagnostic and statistical manual of mental disorders (5th edition) (DSM-5) diagnosis of bipolar disorder (BD) (Type I or II) without current psychoticfeatures, as confirmed by the mini international neuropsychiatric interview (MINI)

• Medically stable on the basis of physical examination, medical history, and vitalsigns performed at screening. Any abnormalities must be consistent with theunderlying illness in the study population. This determination must be recorded inthe participant's source documents and initialed by the investigator

• Have a body mass index (BMI) between 18.0 and 35.0 kilograms per meter square (kg/m^2) inclusive (BMI = weight/height^2)

• A woman of childbearing potential (WOCBP) must have a negative highly sensitiveserum pregnancy test (beta-human chorionic gonadotropin [beta-hCG]) at screening anda negative urine pregnancy test before the first dose of study intervention

Exclusion Criteria:

• Currently meets the DSM-5 criteria for Manic Episode (ME) on the MINI

• Received transcranial magnetic stimulation (TMS), any transcranial electricalstimulation, including transcranial direct current stimulation (tDCS), vagal nervestimulation (VNS) and/or deep brain stimulation (DBS) within 6 weeks prior torandomization

• History of moderate to severe cannabis misuse according to DSM-5 criteria within 6months before screening

• History of malignancy within 5 years before screening (exceptions are squamous andbasal cell carcinomas of the skin and carcinoma in situ of the cervix, or malignancythat in the opinion of the investigator is considered cured with minimal risk ofrecurrence)