.German TTP-Registry (Thrombotic Thrombocytopenic Purpura)

Last updated: May 20, 2022
Sponsor: Johannes Gutenberg University Mainz
Overall Status: Active - Recruiting

Phase

N/A

Condition

Thrombocytopenia And Thrombocytopenia Prevention

Platelet Disorders

Treatment

N/A

Clinical Study ID

NCT05389007
RGTTP
  • Ages > 18
  • All Genders

Study Summary

Open, multi-center, observational, prospective cohort study, only disease-indicated treatment, in patients with clinically diagnosed acquired and congenital TTP regardless of gender, ethnicity, and comorbidities, over the age of 18 for 1.) prospective investigation of patients with TTP in an acute bout and during long-term follow and 2.) assessment of prevalence, course of disease, success of therapy, possible triggers for relapses and possibilities for better diagnosis and prognosis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with clinically diagnosed acquired and congenital TTP regardless of gender,ethnicity, and comorbidities, over the age of 18.
  • Patients incapable to give consent, who are accompanied by a legal representativeduring admission to the study, after the written informed consent of the legalrepresentative.
  • Written informed consent of the patient.

Exclusion

Exclusion Criteria:

  • Patients who are not able to understand the German or English language.
  • Patients who are permanently unable to communicate and who are not accompanied by alegal representative.

Study Design

Total Participants: 156
Study Start date:
July 08, 2016
Estimated Completion Date:

Study Description

1.) Identification of predictive markers for morbidity and mortality in acute TTP and in TTP relapses using a prospective long-term registry and 2.) Investigation of the pathophysiological processes in acute bouts and in remission by recording the clinical symptoms and diagnostics for a better understanding of the course of the disease, optimization of diagnostic procedures and their correlation with the clinical course, recording of therapy response of all therapeutic options in acute bouts, observation of current treatment options to evaluate outcome and prognostic markers and recording of clinical and laboratory chemical data during follow-up to assess long-term morbidity.

Connect with a study center

  • University Hospital Mainz, Hematology

    Mainz, 55131
    Germany

    Active - Recruiting

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