DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution

Inclusion Criteria:

Patients are eligible for the study if all of the following apply:

• Are aged 35 years or above

• Have baseline CT study with at least one incidentally detected solid or part-solid (must have a solid component >=80%) pulmonary nodule that:

• is not fully calcified

• Is 5-30mm inclusive in maximum axial diameter for the whole lesion measuredusing manual electronic callipers

• Have baseline CT study that includes at least one series that meets all of thefollowing (training for this will be provided):

• Is of a type that meets VNC instructions for use

• Comprises at least one full-inspiration breath-hold scans without a high degreeof contrast media and does not exhibit quality issues (e.g., motion artefacts)

Exclusion Criteria:

Patients will be excluded from the study if any of the following apply:

• Have received a diagnosis for cancer in the last 5 years

• Have thoracic implants that impact the image appearance of the nodule

• Have more than five reported pulmonary nodules of any size or type excluding fullycalcified nodules (this criterion is used as a proxy due to the risk of being aninfection or metastasis)

• Have one or more additional nodules where any of the following applies:

• Are already undergoing follow-up according to pulmonary nodule managementstandard care

• Pure ground glass opacity (GGO) of >=5mm in maximum axial diameter for thewhole lesion measured using manual electronic callipers

• >30mm in maximum axial diameter for the whole lesion measured using manualelectronic callipers