Systemic Transthyretin Amyloidosis: Carpal Tunnel Syndrome in a Portuguese Population

Last updated: October 18, 2023
Sponsor: Universidade do Porto
Overall Status: Active - Recruiting

Phase

N/A

Condition

Carpal Tunnel Syndrome

Amyloidosis

Treatment

Synovial biopsy and Cardiac scintigraphy with [99mTc]Tc-DPD

Clinical Study ID

NCT05409833
CarPoS
  • Ages > 60
  • All Genders

Study Summary

Systemic transthyretin amyloidosis is an aging-related disorder. It is usually associated with cardiac disease but also extends to other organs. Recent studies found that idiopathic carpal tunnel syndrome patients may have amyloid deposition in tenosynovial tissue. The main aims of this project are the characterization of the association between idiopathic carpal tunnel syndrome and transthyretin amyloidosis and its evaluation as a predictive factor of cardiac amyloidosis

Eligibility Criteria

Inclusion

Inclusion Criteria: . Patients aged ≥ 60 years old with symptomatic idiopathic carpal tunnel syndrome or otherhand surgery indications.

Exclusion

Exclusion Criteria: . Diabetes mellitus, hypothyroidism, hemodialysis, rheumatoid arthritis, and otherinflammatory arthropathies, multiple myeloma, gout, chondrocalcinosis, Colles fracture,space-occupying lesions, and infectious synovitis.

Study Design

Total Participants: 100
Treatment Group(s): 1
Primary Treatment: Synovial biopsy and Cardiac scintigraphy with [99mTc]Tc-DPD
Phase:
Study Start date:
June 01, 2020
Estimated Completion Date:
June 01, 2025

Connect with a study center

  • Centro Hospitalar Universitário São João

    Porto, 4200-319
    Portugal

    Active - Recruiting

  • Faculty of Medicine (FMUP)

    Porto, 4200-319
    Portugal

    Active - Recruiting

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