Effect of Opioid-free Anesthesia on PostOperative Nausea and Vomiting in Patients Undergoing Video-assisted Thoracoscopic Surgery

Last updated: March 15, 2025
Sponsor: Beijing Chao Yang Hospital
Overall Status: Completed

Phase

N/A

Condition

Stomach Discomfort

Colic

Vomiting

Treatment

Standard general anesthesia (OA)

Opioid-Free Anesthesia (OFA)

Clinical Study ID

NCT05411159
2022020817
  • Ages 18-65
  • All Genders

Study Summary

This study aimed to verify whether an Opioid-free Anesthesia (OFA) could effectively reduce the incidence of PONV after thoracoscopic-assisted surgery compared with standard general anesthesia (OA) regimens.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Inpatients planning elective thoracoscopic lobectomy or wedge resection undergeneral anesthesia

Exclusion

Exclusion Criteria:

  • ASA classification > 4

  • BMI>35kg/m2

  • Unable to communicate before surgery

  • Received radiation therapy, chemotherapy, opioids or hormonal drugs within 14 daysbefore surgery

  • Anticipated intolerance to the anesthesia protocol of this study

  • Expect prolonged mechanical ventilation after surgery

  • Decline

Study Design

Total Participants: 168
Treatment Group(s): 2
Primary Treatment: Standard general anesthesia (OA)
Phase:
Study Start date:
June 07, 2022
Estimated Completion Date:
November 30, 2024

Study Description

Postoperative Nausea and Vomiting (PONV) is one of the most common complications after general anesthesia, which significantly reduces postoperative comfort and satisfaction of patients perioperatively. Meta-analysis showed that Opioid-free Anesthesia (OFA) significantly reduced the risk of postoperative PONV events in patients undergoing gynecology, breast, and abdominal surgery compared with standard general anesthesia (OA). The main hypothesis of the study is that an OFA could reduce the incidence of PONV in patients after thoracoscopic-assisted surgery than OA.

Connect with a study center

  • Beijing Chaoyang Hospital

    Beijing, Beijing 100020
    China

    Site Not Available

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