Definition for Biliary Atresia Associated Cholangitis After Surgery

Last updated: July 15, 2022
Sponsor: Nanjing Children's Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Liver Disorders

Liver Disease

Gall Bladder Disorders

Treatment

N/A

Clinical Study ID

NCT05464303
ERBAAC
  • Ages < 16
  • All Genders

Study Summary

Cholangitis is the most common postoperative complication of biliary atresia, with a reported incidence of 40-90%, which seriously affects the surgical effect, survival rate and the quality of life and prognosis of patients. Without of direct evidence, the diagnosis of cholangitis sometimes is difficult to make, thus most of them are diagnosed based on the symptoms of children. According to literature reports, different centers and regions have different diagnostic criteria for postoperative cholangitis after hepatic portoenterostomy, which has a great influence on the accuracy of the incidence rate and appropriate treatment of cholangitis, and also brings differences in the analysis of the causes and prognostic factors of cholangitis.

Based on the above reasons, we used the Delphi method,in which worldwidely 48 experts participated in, to establish the diagnostic scoring system for postoperative cholangitis after biliary atresia.

Now we aimed to verify the specificity and sensitivity of the new scoring system through clinical cases, in order to unify and standardize the diagnostic criteria and provide help for the diagnosis and treatment of cholangitis after biliary atresia.

Eligibility Criteria

Inclusion

Inclusion Criteria:

① Admission time: 2019.01.01-2021.12.31;

② The first diagnosis after discharge was cholangitis

Exclusion

Exclusion Criteria:

① Cholangitis after non-Kasai procedure;

  • Postoperative cholangitis of biliary atresia not operated in the unit; ③ Patient hasbeen treated in other hospitals during this episode; ④ The treatment period forcholangitis is not completed or the patient is discharged automatically.

Study Design

Total Participants: 500
Study Start date:
July 15, 2022
Estimated Completion Date:
December 31, 2022

Connect with a study center

  • NJMU

    Nanjing, Jiangsu
    China

    Active - Recruiting

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