Cushing's Syndrome Before and After Treatment (CORRECT)

Last updated: April 1, 2025
Sponsor: University of Aarhus
Overall Status: Active - Recruiting

Phase

N/A

Condition

Female Hormonal Deficiencies/abnormalities

Cushing's Disease

Treatment

no intervention, as this is an observational study

Clinical Study ID

NCT05521529
1-10-72-41-22
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to prospectively study patients with Cushing's syndrome before and after treatment, with a special emphasis on physical function, quality of life, and circadian rhythms.

The hypotheses are:

  • Cushing's syndrome negatively impacts health-related quality of life (HRQoL) and physical functioning

  • Cushing's syndrome is associated with altered circadian rhythms at the whole body level and in peripheral target tissues.

  • These complications partially reverse following disease control.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • New (≤ 2 months) diagnosis of Cushing's syndrome (CS) of endogenous etiology:

  • ACTH-dependent CS

  • ACTH-independent CS

  • Age >18 years

  • Written informed consent

Exclusion

Exclusion Criteria:

  • Active cancer

  • Iatrogenic or malignant cause of CS such as adrenocortical carcinoma

  • Chronic heart failure (New York Heart Association class IV)

  • Chronic kidney disease Chronic Kidney Disease stage ≥3 (eGFR >30 ml/min)

  • Liver disease in the form of cirrhosis

  • Deemed unable to complete the study safely by investigator

Study Design

Total Participants: 20
Treatment Group(s): 1
Primary Treatment: no intervention, as this is an observational study
Phase:
Study Start date:
February 16, 2023
Estimated Completion Date:
November 30, 2032

Connect with a study center

  • Department of Endocrinology and Internal Medicine

    Aarhus, State 8200
    Denmark

    Active - Recruiting

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