T-mult: Exploring the Impact of TMS Induced Virtual Lesions on the Multimodal Brain Network and Cognition

Last updated: May 26, 2025
Sponsor: Amsterdam UMC, location VUmc
Overall Status: Completed

Phase

N/A

Condition

N/A

Treatment

repetitive transcranial magnetic stimulation (rTMS)

Clinical Study ID

NCT05542641
NL82268.029.22
  • Ages 20-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

T-mult is an experimental study using low-frequency (1Hz) single-sesson rTMS to the DLPFC (versus sham rTMS) to explore the effect of virtual lesions on the brain network and cognition in 100 healthy adults (20-65 years old).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age between 20 and 65 years old

  • Native Dutch speaker

  • Able to provide written informed consent

Exclusion

Exclusion Criteria:

  • History of diagnosed neurological or psychiatric disease (including traumatic headinjury)

  • Current and regular use of centrally acting drugs (recreational or prescribed,including analgesics), including the use of alcohol ~8 hours prior to an appointment

  • Presence of any contraindications for MRI, MEG, or TMS (including resting motorthreshold >75% of maximum stimulator output or no useful motor-evoked potentialelicitable)

  • Previous rTMS treatment

Study Design

Total Participants: 102
Treatment Group(s): 1
Primary Treatment: repetitive transcranial magnetic stimulation (rTMS)
Phase:
Study Start date:
April 25, 2023
Estimated Completion Date:
May 26, 2025

Connect with a study center

  • VU University Medical Centers, location VUmc

    Amsterdam, 1081 HV
    Netherlands

    Site Not Available

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