Ecopipam Tablets to Study Tourette's Disorder in Children, Adolescents and Adults

Inclusion Criteria:

• ≥ 6 years of age

• ≥ 18 kg (~ 40 lbs.)

• TD diagnosis and both motor and vocal tics that cause impairment with normalroutines

• Minimum score of 20 on the YGTSS-R Total Tic Score

• May not be taking any medications used to treat motor or vocal tics for at least 14days prior to Baseline.

• Effective contraception during the study and 30 days after last study dose forsexually active subjects

Exclusion Criteria:

• Previous exposure to ecopipam

• Certain mood or psychiatric disorders (i.e., dementia, bipolar disorder,schizophrenia, major depressive disorder)

• Unstable medical illness or clinically significant lab abnormalities

• Risk of suicide

• Pregnant or lactating women

• Moderate to severe renal insufficiency

• Hepatic insufficiency

• Positive urine drug screen

• Unstable doses for drugs to treat anxiety, depression, Attention DeficitHyperactivity Disorder

• Certain medications that would lead to drug interactions

• Recent behavioral therapy