Comparison Between the Non-powered AEON™ Endostapler and Echelon FLEX™ Powered Plus Stapler With Regards to the Closure of Lung Tissue After Lung Resection in the Presence of Severe Lung Emphysema

Last updated: February 20, 2025
Sponsor: University Hospital, Basel, Switzerland
Overall Status: Completed

Phase

N/A

Condition

Emphysema

Thoracotomy

Treatment

Echelon FLEX™ Powered plus Stapler (according to manufacturer medical device classification IIb)

Non-powered AeonTM Endostapler (according to manufacturer medical device classification IIb)

Clinical Study ID

NCT05628415
2022-D0079; kt22Lardinois3
  • Ages > 18
  • All Genders

Study Summary

Prolonged air leak is reported in up to 60 to 75% of patients after lung operation in the presence of severe lung emphysema. The effect of the non-powered AEONTM Endostapler as compared to the Echelon FlexTM Powered plus stapler on the volume and duration of air leak and on the time to chest drain removal after lung operation in the presence of severe lung emphysema will be investigated in a randomized, prospective, single-blinded clinical trial.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Informed Consent signed by the subject

  • Patients discussed in the interdisciplinary emphysema treatment board and found tohave the indication for a LVRS or patients who meet the criteria in agreement withpneumology recommendation for bilateral or unilateral LVRS with pulmonary emphysema (all morphologies including chronic obstructive pulmonary disease (COPD) GOLD IIIand IV) or patients operated for other Pathology other than lung emphysema requiringlung resection in the presence of severe lung emphysema.

Exclusion

Exclusion Criteria:

  • non-bullous pulmonary emphysema

  • Severely impaired carbon monoxide diffusing capacity (≤ 20% of predicted value,One-second capacity (FEV1) ≤ 20% of predicted value with a homogeneous emphysemamorphology

  • Patients with severe pulmonary arterial hypertension (mPAP > 35 mmHg) and aresymptomatic

  • Significant (i.e. clinically relevant and symptomatic) Coronary Arterial Disease (CAD)

  • Inability to follow the procedures of the study, e. g. due to language problems,psychological disorders, dementia, etc. of the participant

  • Enrolment of the investigator, his/her family members, employees and other dependentperson

  • Current enrolment in another clinical trial studying an experimental treatment

  • Pregnancy

Study Design

Total Participants: 19
Treatment Group(s): 2
Primary Treatment: Echelon FLEX™ Powered plus Stapler (according to manufacturer medical device classification IIb)
Phase:
Study Start date:
November 15, 2022
Estimated Completion Date:
February 20, 2025

Study Description

Patients with severe lung emphysema Grad III or IV scheduled for an operation by video-assisted thoracic surgery (VATS) or open method at the Department of Thoracic Surgery at the University Hospital Basel will be pre-screened in terms of inclusion and exclusion criteria. Before the operation, a randomization envelope is opened in the operation room, in which it is specified on which side and with which method the lung tissue will be closed. If bilateral surgery is planned, the other side is automatically closured using the other method. If for example the non-powered AEONTM Endostapler is randomly allocated to the left side, the right side is automatically operated with the Echelon FLEXTM Powered plus Stapler and vice versa. In cases of a unilateral surgery a random stapler as stated in the envelop would be allocated for that side in question. On the day of the operation, postoperative air leak will be measured quantitatively in ml per minute immediately, 2h, 4h, 8h, and 12h after skin closure. Starting on the first postoperative day, this is done twice a day at 8 am and 5 pm until the air leak stops or another surgery must be performed. Cessation of air leak is the case when a value of 0ml/min or two consecutive values under 30 ml/min by use of thoracic drainage Medela- Topaz™ system are read by the investigator.

Connect with a study center

  • University Hospital of Basel, Department of Thoracic Surgery

    Basel, 4031
    Switzerland

    Site Not Available

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