Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders

Inclusion Criteria:

• Acquired hypogonadotropic hypogonadism (hypothalamic amenorrhea, aka functionalhypothalamic amenorrhea)

• Confirmed diagnosis by medical provider supported by low sex steroids in thesetting of low or inappropriately normal gonadotropins]

• Normal blood pressure (systolic BP < 140 mm Hg, diastolic < 90 mm Hg)

• Laboratory Studies:

• Hemoglobin no less than 0.5 g/dL below the lower limit of the reference rangefor normal women

• Negative serum hCG pregnancy test at screening (additional urine pregnancy testwill be conducted prior to drug administration)

• Not using hormonal replacement or willing to complete an appropriate washout forthat particular medication and method of administration

• No current or recent use of a medication that, in the opinion of a studyinvestigator, can modulate the reproductive axis or willing to complete anappropriate washout for that particular medication and method of administration

Exclusion Criteria:

• Any condition (medical, mental, or behavioral) that, in the opinion of a studyinvestigator, would likely interfere with participation in/completion of theprotocol

• Excessive alcohol consumption (>10 drinks/week) and/or active use of illicit drugs

• Any active use of marijuana will be evaluated by a study medical professional todetermine if it may impact study participation. Individuals who regularly usemarijuana may be asked to washout as referenced in the medication washout sectionbelow

• Pregnant or trying to become pregnant

• Breast feeding

• History of bilateral oophorectomy (ovaries were removed)